Glycogen Phosphorylase

Description

Year 2 (Insulin & Glucagon) Quiz on Glycogen Phosphorylase, created by gina_evans0312 on 23/10/2013.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question 1

Question
Which form of Glycogen Phosphorylase is relatively inactive?
Answer
  • Phosphorylase A
  • Phosphorylase B

Question 2

Question
In phosphorylase B, where is the N terminus?
Answer
  • Floating free in the cytoplasm
  • Attached to the protein body
  • Unattached from protein

Question 3

Question
Which of the forms of glyocgen phosphorylase is most effected by cellular AMP/ATP levels?
Answer
  • Phosphorylase A
  • Phosphorylase B

Question 4

Question
Which of the following phosphorylates Glycogen Phosphorylase?
Answer
  • Phosphorylase B Kinase
  • Phosphorylase A Kinase
  • Phosphorylase Kinase

Question 5

Question
What protein causes the dephosphorylation of phosphorylase?
Answer
  • Protein phosphatase
  • Protein phosphorylase
  • Prokein Kinase P

Question 6

Question
What is needed for the reaction of Phosphorylase B --> A to reverse itself?
Answer
  • Water (and a lack of inhibiting AMP)
  • Water (and a lack of inhibiting ATP)
  • Water (and a lack of inhibiting GMP)

Question 7

Question
What is different about Phosphorylase A to B?
Answer
  • Ser14 has been phosphorylated
  • Tyr14 has been phosphorylated
  • Thr14 has been phosphorylated

Question 8

Question
What difference does phosphorylating Glycogen phosphorylase make?
Answer
  • Makes the relaxed form much more likely
  • Makes the taut form much more likely
  • Deactivates it entirely

Question 9

Question
How does phosphorylase B Kinase connect Glycogen Phosphorylase levels to the level of stimulation?
Answer
  • It is activated by Ca2+- when the muscle is stimulated, glucose is needed and so glycogen is broken down
  • It is deactivated by Ca2+- when the muscle is stimulated, glucose is not needed and so glycogen isn't broken down

Question 10

Question
What part of Phosphorylase B Kinase binds to Calcium?
Answer
  • Calmodulin
  • Calsequestrin
  • Troponin C

Question 11

Question
Which parts of phosphorylase B kinase are regulatory?
Answer
  • Alpha and beta
  • Alpha and gamma
  • Gamma and beta

Question 12

Question
Which part of phosphorylase B kinase is catalytic?
Answer
  • Gamma
  • Delta
  • Beta

Question 13

Question
In phosphorylase B kinase's Ca2+ binding sites, what are the affinities?
Answer
  • 2 high 2 low
  • 4 high
  • 4 low

Question 14

Question
What protein causes the phosphorylation of Phosphorylase B Kinase?
Answer
  • cAMP dependent Protein Kinase
  • Adenylate Cyclase
  • Glycogen Phosphorylase

Question 15

Question
What is another name of cAMP dependent protein kinase?
Answer
  • Protein Kinase A
  • Protein Kinase B
  • Protein Kinase C

Question 16

Question
What is the role of inhibitor one?
Answer
  • To bind to protein phosphatase, activating it
  • To bind to protein phosphatase, inhibiting it
  • To bind to protein kinase A, activating it

Question 17

Question
What is contained in the N terminus domain of Glycogen Phosphorylase?
Answer
  • The catalytic site
  • The allosteric effector site
  • The regulatory subunit

Question 18

Question
How does glycogen get from it's binding domain to the catalytic site?
Answer
  • A hydrophobic tunnel
  • A hydrophillic tunnel
  • A lipophobic tunnel

Question 19

Question
Why is glycogen phosphorylase's site in a deep groove?
Answer
  • To prevent AMP from entering
  • To prevent ATP from entering
  • To prevent water from entering

Question 20

Question
What happens if water enters the active site?
Answer
  • Nothing
  • The enzyme is deactivated
  • Hydrolysis occurs instead of phosphorolysis
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