11751807
Description
Quiz by Christina Marshall, updated more than 1 year ago
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Created by Christina Marshall
over 6 years ago
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Question 1
Question
A mutation removes a single base pair within the coding sequence of a gene and inactivates the protein encoded by the gene. Such a mutation is
Answer
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A silent mutation
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A missense mutation
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A nonsense mutation
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A frameshift mutation
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Both b and c
Question 2
Question
Some point mutations lead to an mRNA that produces a shorter polypeptide. This type of mutation is known as a _________ mutation.
Answer
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neutral
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silent
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missense
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nonsense
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chromosomal
Question 3
Question
In which location is a mutation least likely to affect gene function?
Answer
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Promoter
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Coding Region
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Splice Junction
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Intergenic Region
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Regulatory site
Question 4
Question
Mutagens can cause mutations by
Answer
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chemically altering DNA nucleotides
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disrupting DNA replication
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altering the genetic code of an organism
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all of the above
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a and b only
Question 5
Question
The mutagenic effect of UV light is
Answer
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the alteration of cytosine bases and adenine bases
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the formation of adenine dimers that interfere with genetic expression
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the breaking of the sugar-phosphate backbone of the DNA molecule
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the formation of thymine dimers that disrupt DNA replication
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the deletion of thymine bases along the DNA molecule
Question 6
Question
The Ames test
Answer
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provides a way to determine if any type of cell has experienced a mutation
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provides a way to determine if an agent is a mutagen
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allows researchers to experimentally disrupt gene activity by causing a mutation in a specific gene
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provides a way to repair mutation in bacterial cells
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does all the above
Question 7
Question
Xeroderma pigmentosum
Answer
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is a genetic disorder that results in uncontrolled cell growth
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is a genetic disorder in which the NER System is not fully functional
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is a genetic disorder that results in the loss of pigment in certain patches of skin
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results from the lack of DNA polymerase proofreading
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Both b and d are true of this disorder.
Question 8
Question
If a mutation eliminated the function of UvrC, which aspect of nucleotide excision repair would not work?
Answer
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Sensing a damaged DNA site
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Endonuclease cleavage of the damaged strand
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removal of the damaged strand
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synthesis of a new strand, using the undamaged strand as a template
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none of the above
Question 9
Question
Cancer cells are said to be metastatic when they
Answer
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begin to divide uncontrollably
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invade healthy tissue
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migrate to other parts of the body
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cause mutations in other healthy cells
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do all of the above
Question 10
Question
Oncogenes can be produced by
Answer
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missense mutations
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gene amplification
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chromosomal translocation
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retroviral insertion
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all of the above
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