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7232410
Ahmed Frequent Infections
Description
Mind Map on Ahmed Frequent Infections, created by Menna Emam on 10/12/2016.
Mind Map by
Menna Emam
, updated more than 1 year ago
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Created by
Menna Emam
over 7 years ago
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Resource summary
Ahmed Frequent Infections
Immunodeficiency
Characteristic
Recurrent Infections
Such as
Persistent bacterial Infections
Hematological
Opportunistic Infections
Mainly
Candidas (oral thrush)
Forms
White Plaques
Caused by
Candida Albicana
Treatment
Anti-fungal Durgs
Gastrointestinal
Treated by
Gene Therapy
BMT
has
Infection management
done
Pre/Post Transplant
Ethical guidelines
Importantly
Constant
Without infecting harm
Requires
Immunosuppressive therapy
Mainly
Corticosteroids
Cause
Arterial Hypertension
Donor Selection
Based on
ABO typing
HLA Typing
Reduces
Graft Vs. Host rejection
Revaccination
at least
A year post transplant
Selective
Specific vaccines , doses & Routines
Due to
Immunocompromised state
Can be
Secondary
Primary
Such as
SCID
is
Fatal combined absence of T-lymphocyte & B-Lymphocyte function
Including
X-SCID
Results
Low T & NK cells with increased B cells
Due to mutation of gamma chain of IL-2 receptor
Reticular Dysgenesis
Caused by
Absence of Myeloid & Lymphoid cells
Leads to
Few WBC
ADA Deficiency
Leads to
Accumulation of toxic by products with lymphocytes
JAK3 Deficiency
Mutation in Janus Kinase Enzyme
Diagnosed
Either
Prenatal
Through
Amniocentesis
Chronic Villus Sampling
Postnatal
Through
Skin Anergy test
Lateral Neck X-ray
Check
Adenoid Tissue
Lymph Node
Clinical Presentation
Infections
Mainly
Gut
Tract
Diarrhea
Failure to thrive
Thrush
Connor Counseling & consent
Should Include
Assurance that the potential donor is willing to donate, free from inducement
A determination that the potential donor understands that he or she will undertake several risks
Medical Risks
Scar
Pain
Fatigue
Psychosocial Risks
Financial Risks
Bone Marrow Transplant
is
Soft, Spongy tissue found inside the bones
Why
Relapsed disease
Non-functioning bone marrow with a healthy functioning one
Regenerate a new Immune system
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