central monoamines

Description

Neuroscience of Pain Mind Map on central monoamines, created by Cher Bachar on 21/04/2013.
Cher Bachar
Mind Map by Cher Bachar, updated more than 1 year ago
Cher Bachar
Created by Cher Bachar over 11 years ago
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Resource summary

central monoamines
  1. serotonin
    1. Regulation of nociception
      1. endogenous analgesia
        1. Role of 5-HT1 agonists in migrane
        2. Anatomical and functional organisation
          1. RVM
            1. serotonin neurons= NEUTRAL cells
            2. Receptors
              1. 5-HT1
                1. inhibit nociception
                2. 5-HT2/3
                  1. facilitate nociception
                  2. 5-HT7
                    1. periphery-pronociceptive
                      1. spinal cord-antinociceptive
                3. Noradrenaline
                  1. Regulation of nociception
                    1. Anatomical and functional organisation
                      1. NA neurons
                        1. 7 groups in the brainstem

                          Annotations:

                          • A1-A7
                          1. Adrenoceptors
                            1. At spinal level
                              1. Alpha1

                                Annotations:

                                • excitatory via phospholipase C- increased PI and DAG
                                1. Alpha2

                                  Annotations:

                                  • inhibition of adenylyl cyclase- decrease cAMP- like opiod receptors>> main focus because they mimic opiods
                                  1. Beta

                                    Annotations:

                                    • excitation via increase cAMP
                                  2. Phrmacology
                                    1. intrathecal drugs

                                      Annotations:

                                      • injected in the CSF of the spinal cord
                                      1. allpha-adrenoceptor anta
                                        1. blocks Locus coereleus (LC) evoked analgesia
                                          1. blocks PAG/RVM evoked analgesia
                                          2. NA agonists
                                            1. via alpha2 receptors
                                              1. in rats
                                                1. in humans
                                                  1. analgesic effects
                                                  2. side effects
                                                    1. hypotension
                                                      1. sedation
                                              2. Activation
                                                1. electrical or chemical
                                                  1. LC, A7- antinociceptive
                                                2. Descending NA control
                                                  1. Methods
                                                    1. Animals
                                                      1. stimulation of pontine N
                                                        1. electrical
                                                          1. chemical
                                                          2. recording LC neurons
                                                            1. Lesions
                                                              1. electrical of LC
                                                                1. chemical
                                                                2. antagonists
                                                                  1. alpha1/2
                                                                  2. knockouts of alpha2 receptors
                                                                    1. Vital targeting
                                                                    2. Humans
                                                                      1. alpha agonists
                                                                        1. NA re-uptake inhibitors
                                                                      2. Role
                                                                        1. inflammatory pain
                                                                          1. neuropathic pain
                                                                            1. endogenous analgesia
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