4252028
Cytoskeleton: Motility
and Mitosis
- STRUCTURE
- Filapodia
- Extension from the cell which detect
the enviorment around the cell
- contain actin filament
- contain actin filament
- Extension from the cell which detect
the enviorment around the cell
- Stress fibres
- Hold the cell together and keep its
shape as it moves, they stretch and
contract once the cell as extended
- Also bundles of actin
- Also bundles of actin
- Hold the cell together and keep its
shape as it moves, they stretch and
contract once the cell as extended
- Focal Adhesion
- Like mini feet, found on the bottom of cells, they elevate
the cell and links the cytoskeleton to the outside
- Like mini feet, found on the bottom of cells, they elevate
the cell and links the cytoskeleton to the outside
- Lamelapodia
- Bundling of actin filament together, which
cause the cell to move (treadmilling)
- Bundling of actin filament together, which
cause the cell to move (treadmilling)
- Filapodia
- HOW DO CELLS MOVE?
- The actin filament subunits line
up parallel at the leading edge,
- One end polymerised whilst other
broken down, this is called
treadmilling (lost at -, added on +)
- Many F actin do this at the same time
- Many F actin do this at the same time
- The filament moves forward whilst the actin
filament remains the same size
- The actin filament subunits line
up parallel at the leading edge,
- WHY IS CELL MOTILITY
NEEDED?
- Cell Migration
- Chemotaxis
- Destroying pathogen
- Destroying pathogen
- Tissue formation
- Repair of cells
- Repair of cells
- Cancer
- Metastasis
- Metastasis
- Chemotaxis
- Cell Migration
- TERMINOLOGY
- Leading Edge
- Front of the cell
- Front of the cell
- Lagging end
- Back of the cell
- Back of the cell
- Leading Edge
- MITOSIS
- Microtubules
- The are formed from spindle fibre and they attach to the centrosome
of the chromosone, one from each side on every chromosone. They
pull at the same force and chromosones are pulled apart. They then
depolarise and get shorter moving chromosones to opposite sides of
the cell
- The are formed from spindle fibre and they attach to the centrosome
of the chromosone, one from each side on every chromosone. They
pull at the same force and chromosones are pulled apart. They then
depolarise and get shorter moving chromosones to opposite sides of
the cell
- At cytokenesis the actin filament strangulate
inbetween the nuclei by becoming shorter (depolarisation)
- Microtubules
- INTERGRINS
- Receptors which connect the
ECM and the cytoskeleton
- They bind to matrix molecules causing
them to become activated, they relay
activation into the cytoplasm of the cell
- They bind to matrix molecules causing
them to become activated, they relay
activation into the cytoplasm of the cell
- Receptors which connect the
ECM and the cytoskeleton
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