380929
Description
Mind Map by fatimaelfitouri, updated more than 1 year ago
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Created by fatimaelfitouri
over 10 years ago
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RTKs
- Receptor tyrosine kinase (RTK)
- PDGFR
- insulin R
- more than 50 identified
- single polypeptides except insulin R
- structure
- transmembrane
- variety of extracellular domain
- Enter text here
- ligand binding domain in the extracellular region
- a single transmembrane helix
- cytoplasmic region containing a protein tyrosine kinase (TK) domian, carboxyl terminal and juxtamembrane regulatory region
- transmembrane
- induction
- ligand binds to receptor= dimerisation of receptor
- dimerisation promotes autophosphorylation
- ligand binds to receptor= dimerisation of receptor
- some RTKs form oligmers in the absence of activating ligands eg insulin R and IGF1R
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