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Cell Signalling Note

gordonbrad

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RTKs

Description

cell signalling Mind Map on RTKs, created by fatimaelfitouri on 22/11/2013.

Mind Map by fatimaelfitouri, updated more than 1 year ago

	Created by fatimaelfitouri over 11 years ago

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Resource summary

RTKs

Receptor tyrosine kinase (RTK)
PDGFR
insulin R
more than 50 identified
single polypeptides except insulin R
structure
1. transmembrane
2. variety of extracellular domain
3. Enter text here
4. ligand binding domain in the extracellular region
5. a single transmembrane helix
6. cytoplasmic region containing a protein tyrosine kinase (TK) domian, carboxyl terminal and juxtamembrane regulatory region
induction
1. ligand binds to receptor= dimerisation of receptor
2. dimerisation promotes autophosphorylation
some RTKs form oligmers in the absence of activating ligands eg insulin R and IGF1R

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