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3594449
Cell adhesion and migration
Description
University S377 Mind Map on Cell adhesion and migration, created by Sarah Smith on 28/09/2015.
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s377
university
Mind Map by
Sarah Smith
, updated more than 1 year ago
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Created by
Sarah Smith
almost 9 years ago
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Resource summary
Cell adhesion and migration
Adhesion
Cell adhesion molecules (CAMs)
Tight/occluding junctions
Anchoring junctions
Cadherins
Need catenins to bind to actin microfilaments
B-catenin
E-cadherin limits tumour spread, thus is tumour suppressor
Integrins
Alpha chain contains metal coordination complex
Integrins are CAMs that mediate cess migration
Almost all interact with microfilamants, but one interacts with intermediate filaments
MIDAS site need Ca2+ or Mg2+
Focal Adhesions
Hemidesmosomes
Desmosomes
Adherens junctions
Communicating Junctions
Lack of adhesion - tumour development
Interdependent with differentiation
Migration
Multicellular animals
Most cells need a sold support; ECM or other cells.
Cilia and Flagellae: bundles of microtubules...relationship with cytoskeleton
Cells of the nervous system migrate from the neural crest during embryonic development
Pseudopodia: stubby projections at cell's leading edge
Leading edge of cell anchored by integrins
Lamellipodium: sheet of cytosol extended at leading edge
Filopodia: single filamentous extensions
Uropod: trailing edge
Cells need survival signals from basal lamina/neighbouring cells
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bc03b485-b02d-468e-a66b-99885476c840 (image/png)
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