954008
Description
Flashcards by savaniprachi, updated more than 1 year ago
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Created by savaniprachi
over 10 years ago
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| Question | Answer |
| What are the regulatory points in Glycolysis? | Steps 1, 3 and 10. - hexokinase - phosphofructokinase - pyruvate kinase |
| What is hexokinase regulated by? | Glucose-6-phosphate |
| What is PFK-1 regulated by? | Inhibited by ATP. Action reversed by AMP |
| What is pyruvate kinase regulated by? | Inhibited by ATP and Acetyl-coA Activated by fructose-1,6 bisphosphate (step 4) |
| What happens in tarui disease? | The cells cannot convert fructose 6-phosphate to fructose 1,6-bisphosphate (step 3) therefore there is a build up of glycogen in muscles. |
| What happens if there is a deficiency of pyruvate kinase? | Less ATP production, RBC short half life and lyse easily |
| Under anaerobic conditions, what is pyruvate converted to? | Lactate |
| What activates the PDH complex? | AMP, NAD+, coA |
| What inhibits PDH activity? | ATP, NADH, Acetyl CoA |
| Do high concentrations of the end products (ATP and NADH) stimulate the cycle? | No they inhibit it. Substrates like NAD+ and ADP stimulate the cycle |
| How does sodium fluoroacetate affect the Krebs cycle? | It inhibits formation of isocitrate therefore causing a build of of citric acid |
| What are some of the effects of acute exposure and serious poisoning of sodium fluoroacetate? | Nausea vomiting and diarrhoea. Serious poisoning can cause seizures, comas, respiratory depression among other cardiac symptoms |
| What is Beri Beri and how does it affect the Krebs cycle? | Vitamin B1 (thiamine) deficiency. Thiamine phosphate is required as a part of pyruvate dehydrogenase and α-ketoglutarate dehydrogenase. It results to high levels of pyruvate and α-ketoglutarate in blood. |
| What type of symptoms is Beri Beri characterised by? | Neurological and cardiac |
| What kind of symptoms would you expect from Beri Beri? | Limb pain, weak muscles, distorted skin sensation. May be enlargement of heart with low cardiac output |
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