280 - Myocardial Action Potential (add)

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Cardiovascular Flashcards on 280 - Myocardial Action Potential (add), created by Victoria Wright on 30/05/2017.
Victoria Wright
Flashcards by Victoria Wright, updated more than 1 year ago
Victoria Wright
Created by Victoria Wright almost 7 years ago
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Question Answer
Describe Phase 0 rapid upstroke and depolarization—voltage-gated Na+ channels open
Describe Phase 1 initial repolarization—inactivation of voltage-gated Na+ channels. Voltage-gated K+ channels begin to open.
Describe Phase 2 plateau—Ca2+ influx through voltage-gated Ca2+ channels balances K+ efflux. Ca2+ influx triggers Ca2+ release from sarcoplasmic reticulum and myocyte contraction.
Describe Phase 3 rapid repolarization—massive K+ efflux due to opening of voltage-gated slow K+ channels and closure of voltage-gated Ca2+ channels.
Describe Phase 4 resting potential—high K+ permeability through K+ channels
During Phase 0, there is rapid _________ and _________ Rapid upstroke and depolarization
During Phase 0, voltage-gated NA+ channels _________ Open
During Phase 1, there is _________ of voltage gated Na+ channels. Inactivation
During Phase 1, voltage-gated _________ begin to open K+ channels
During Phase 2, Ca2+ influx through voltage-gated Ca2+ channels balances _________ K+ efflux
During phase 2, _________ influx triggers Ca2+ release from sarcoplasmic reticulum and myocyte contraction. Ca2+
During phase 2, Ca2+ influx triggers Ca2+ release from _________ _________ and _________ _________ Sarcoplasmic reticulum and myocyte contraction
During phase 3, massive _________ due to opening of voltage-gated slow K+ channels and closure of voltage-gated Ca2+ channels. K+ efflux
During phase 3, massive K+ efflux due to opening of voltage-gated slow K+ channels and closure of _________ Voltage-gated Ca2+ channels
During phase 4, high K+ permeability through _________ K+ channels
Cardiac muscle action potential has a plateau which is due to what? Cardiac muscle action potential has a plateau, which is due to Ca2+ influx and K+ efflux.
Cardiac muscle contraction requires what to induce Ca2+ release from sarcoplasmic reticulum (Ca2+-induced Ca2+ release)? Cardiac muscle contraction requires Ca2+ influx from ECF to induce Ca2+ release from sarcoplasmic reticulum (Ca2+-induced Ca2+ release).
Cardiac muscle contraction requires Ca2+ influx from ECF to induce what? Cardiac muscle contraction requires Ca2+ influx from ECF to induce Ca2+ release from sarcoplasmic reticulum (Ca2+-induced Ca2+ release).
Cardiac myocytes are electrically coupled to each other by what? Cardiac myocytes are electrically coupled to each other by gap junctions.
What are electrically coupled to each other by gap junctions? Cardiac myocytes are electrically coupled to each other by gap junctions.
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