61258
Description
Flashcards by becki_fernandes, updated more than 1 year ago
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Created by becki_fernandes
over 11 years ago
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| Question | Answer |
| name and explain the 4 stages of producing an antigen receptor | 1. gene rearrangment - codes for receptor, 2. lineage committment - chooses B or T cells, 3. Education gets rid of autoreactive or non-resposive cells 4. functional maturation - achieve an appropriate affinity for MHC |
| whats happens in equie SCID | no VDJ recombination, so no T/B cells produced |
| what is central tolerance? | if thymocyte reacts strongly to self-MHC then it will be deleted prevents autoimmunity |
| what is self tolerance? | if T cell is unable to recognise a self peptide bound to a self-MHC then it will be deleted (has to recognise when its a self antigen and not attack so it knows when to attack a foreign antigen) |
| whta are lymphocytes derived from? | pluripotent haematopoetic stem cells |
| where do T and B cells mature? | B - bone marrow, T- thymus |
| what do B cells recognise? | native proteins |
| what do T cells recognise? | degraded proteins bound to MHC |
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