48705
Description
Flashcards by Bhavi Mistry, updated more than 1 year ago
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Created by Bhavi Mistry
over 11 years ago
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| Question | Answer |
| Neurobiology of ADHD: | Cortical hypofunction Subcortical + subcortical regulation imbalance Catecholamine imbalance (coffee analogy) |
| PFC: | Regulation of behaviour, attention and affect using representational knowledge |
| DA | PFC: Decreases "noise" via activation of D1Rs |
| Clonidine | Alpha 2 antagonist Treatment of impulsivity |
| Desipramine | NA TCA Impulsivity treatment |
| Addiction | Correlation between low D2R numbers and addiction (+ liking the drug) Loss of control pathways - disruption of balance and ability to make rational decisions |
| Diseases of hypodopaminergic function | Cocaine addiction Alcoholism Obesity |
| alpha 2 receptors | Increase food intake Central regulation of food control |
| 5HT 2C Rs | Decrease food intake Central control of food intake |
| Monoamines | 5HT and NA Peripheral regulation of food intake |
| Beta 3 adrenoceptor | Increases thermogenesis Peripheral regulation of food intake |
| Hormonal control of feeding | NPY (leptin) Melanocrotin Galantin Insulin |
| Phentermine | Sympathomimetic Decreases feeding |
| Fenfluramine | SSRI Decreasing addiction |
| Rimonanabant | Selective CBIR blocker Control of addiction/feeding |
| Lorcaserin | Selective 5HT2C antagonist decrease of food intake |
| Orlistat | lipase inhibitor Peripheral treatment of obesity |
| NA | Locus coeruleus Vigilance |
| 5HT | Impulse control and cognitive flexibility |
| DA | Drive |
| Atomexetine | ADHD treatment Cognitive enhancer NA>DA/5HT |
| Venaflaxine | Anxiety and eating disorders SSRI 5HT>NA>>DA |
| Sibutramine | Eating disorders SSRI 5HT>>NA>>DA |
| Methylphenidate | ADHD Cognitive enhancer NA/DA>5HT |
| Buproprion | Smoking cessation |
| ADHD Core symptoms | Inattention Impulsivity Hyperactivity |
| ADHD Treatment: | Methylphenidate and atomoxetine Increases NA/DA, restores balance, improves function |
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