Antidepressants

Description

under grad Neuro-pharmacology Flashcards on Antidepressants, created by Bhavi Mistry on 17/04/2013.
Bhavi Mistry
Flashcards by Bhavi Mistry, updated more than 1 year ago
Bhavi Mistry
Created by Bhavi Mistry over 11 years ago
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Resource summary

Question Answer
Iproniazid Irreversible non-selective MAO inhibitor
Moclobemide Reversible MAO Inhibitor Depression and social anxiety
Phenelzine Non-selective irreversible MAO inhibitor
Amitriptyline TCA
Clomipramine TCA
Desipramine TCA
Desipramine TCA
Fluoxetine SSRI
Paroxetine SSRI
Citalopram SSRI
Reboxitine NRI
Venflaxine serotonin-norepinephrine reuptake inhibitor (SNRI)
Trazodine serotonin antagonist and reuptake inhibitor (SARI)
Agomelatine MT2 antagonist 5HT2 antagonist
Stress - depression progression Leads to an increase in GLU transmission and cortisol, but decreases Dopamine/monoamine transmission Decrease in neurogenesis, increase in neural apoptosis Increase in depressive symptoms
MAOA Is Degrade 5HT
MaOB Is Degrade DA and NA
Side effects of MAO Is Muscarinic (M1) Postural hypertension (A1) Sedation (H1) weight gain (5ht2)
Tricyclic antidepressants Inhibits ma reuptake (5ht and na) Some alpha 2 adrenoceptor antagonism
Side effects of tricyclic antidepressants Histamine Muscarininc Alpha 1 5HT2 Cardiotoxicity (binding site on heart)
NARIs + SSRIs + SNRIs (Selective reuptake inhibitors) prevent 5HT and NA reputake Lack/reduced TCA side effects
NARIs + SSRIs + SNRIs (Selective reuptake inhibitors) prevent 5HT and NA reputake Lack/reduced TCA side effects
5HT3 side effects of selective re-uptake inhibitors Nausea Anorexia
5HT2 side effects of selective re-uptake inhibitors Insomnia Sexual dysfunction 5HT syndrome (suicide - adolescents only)
NA related side effects of selective re-uptake inhibitors Insomnia Constipation Sweating Tachycardia Anxiety, irritability, aggression
Mirtazipine alpha 2 antagonist 5HT 2 + 3 antagonist Does not antagonise 5HT1 (beneficial effects still present - TCA usually block 5HT1 --> negative side effects)
Atypical drugs SNRI (Serotonin - NA RI) SSRI + 5HT2 antagonist SNRI + 5HT2 antagonist Alpha 2 and 5HT antagonist
Lithium Replaces Sodium decreasing excitability Alters signalling via 2nd messengers Gene expression first line therapy in bipolar disorders Mood stabiliser
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