311841
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 11 years ago
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| Question | Answer |
| A monomer/dimer/heterodimer? | Dimer |
| How many membrane spanning loops in each monomer? | 6 |
| Where is the catalytic site? | Inside the cell |
| What activates adenylate cyclase? | The alpha subunit of Gs protein |
| What effect does the binding of the alpha subunit have? | The two halves of the catalytic site combine and activate |
| What does adenylate cyclase produce? | 3,5-cAMP |
| Why cAMP? A variety of hormones... | can activate the same pathway in different tissues |
| Why cAMP? A hormone can activate... | Different pathways in different tissues |
| Why cAMP? The same hormone doesn't have to... | Activate the same pathway, even if the pathway's only regulated by one mechanism |
| What is cAMP (as part of the cascade)? | A secondary messager |
| What effect does the cholera toxin have on Adenylate Cyclase? | Binds ADP-Ribose to the alpha-s subunit, which prevents it rebinding to the g-protein |
| What effect does the pertussis toxin have on g-protein alpha subunit? | Binds ADP-Ribose to the alpha-i subunit, which prevents it separating from the g-protein |
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