5395403
Description
Quiz by Sam Watkins, updated more than 1 year ago
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Created by Sam Watkins
over 8 years ago
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Question 1
Question
what does NCE mean?
Answer
-
New clinical entity
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National chemical entity
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National clinical entity
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New chemical entity
Question 2
Question
biological drugs (also known as [blank_start]biologics[blank_end]) are [blank_start]large[blank_end] molecule drugs. They are usually [blank_start]proteins[blank_end] such as [blank_start]peptides[blank_end] or antibodies but could be a nucleic acid. When discovered they are referred to as a [blank_start]NBE[blank_end]
Answer
-
biologics
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chemologics
-
biologists
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large
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small
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under 500 daltons
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proteins
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carbohydrates
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vitamins
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peptides
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starches
-
glucose
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NBE
-
NBB
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NBC
-
NBA
Question 3
Question
a blockbuster drugs earns over $10 billion a year
Answer
- True
- False
Question 4
Question
where DON'T novel small molecules come from
Answer
-
Nature
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Endogenous compounds
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In silico drug design
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you too drugs
Question 5
Question
which of the following is NOT a reason why analogue synthesis is required for endogenous lead compounds?
Answer
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natural ligand may have undesirable duration of action
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natural ligand may be metabolised too quickly
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natural ligand may be chemically unstable
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natural ligand may not have pharmacophore
Question 6
Question
synthetic drugs can be designed with computer modelling software
Answer
- True
- False
Question 7
Question
a me too drug has a similar structure to an existing drug, modified enough to make the compound [blank_start]novel[blank_end], but not so much that [blank_start]activity[blank_end] is affected.
Answer
-
novel
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similar
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typical
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normal
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activity
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functional groups
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side effects
Question 8
Question
which one of the following is true
Answer
-
side effects caused by drugs are never useful
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side effects from drugs can be useful by providing a new lead compound for the same condition
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side effects from drugs can be useful by providing a new lead compound for a different condition
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side effects from drugs are always useful even if no new lead compounds are found
Question 9
Question
The definition for a lead compound is - a novel compound discovered to have pharmaceutical potential which is a good starting point for drug development.
Answer
- True
- False
Question 10
Question
natural product derivatives are a natural derivative of a synthetic molecule
Answer
- True
- False
Question 11
Question
Natural product derivatives are used as drug compounds because they are [blank_start]less[blank_end] complex and [blank_start]smaller[blank_end] so easier to deliver, and possibly [blank_start]easier to deliver[blank_end]. The active part of the molecule may be used to save [blank_start]time and money[blank_end].
Answer
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less
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more
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equally as
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smaller
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larger
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have a higher LogP
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easier to deliver
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more lipinski like
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better formulated as creams
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time and money
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space
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wastage and filtration
Question 12
Question
Which of the following are challenges with natural products
Answer
-
chrial centres which leads to 10,000's of isomers
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unusual functional groups causes complex chemistry
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difficult and ineffective multistep synthesis
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novel structures means scientists cannot predict LogP values
Question 13
Question
The large molecular weight of many natural products causes:
Answer
-
I.V to often be the route of administration
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Good absorption through SGLT channels in the duodenal epithelium
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them to be stable in the stomach due to oxygen (ether) groups
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