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Autoimmunity

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Questions on autoimmunity
ivenkat
Quiz by ivenkat, updated more than 1 year ago
ivenkat
Created by ivenkat over 9 years ago
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Question 1

Question
Autoimmunity is characterized by all the following except
Answer
  • It is when your immune system is acting against you
  • These are acute disease with evidence of active infection
  • It is due to failure of tolerance (both central and peripheral)
  • none of the above

Question 2

Question
Negative selection in the bone marrow and thymus means removal of self reactive antigen during development
Answer
  • True
  • False

Question 3

Question
All of the following are a feature of peripheral tolerance except?
Answer
  • No lymphocyte access to some tissues - ignorance
  • Induction of anergy in autoreactive B and T cells
  • Suppression of autoimmune responses by regulatory T cells - Foxp3
  • Expression of tissue specific protein in thymus - Aire

Question 4

Question
Central deletion or inactivation of newly formed lymphocytes is the first checkpoint of self-tolerance
Answer
  • True
  • False

Question 5

Question
Autoimmune Regulator (AIRE) is essential for acquisition of central T cell tolerance
Answer
  • True
  • False

Question 6

Question
APECED syndrome is due to inactivating mutation of Foxp3
Answer
  • True
  • False

Question 7

Question
all of the following are true about IPEX syndrome except
Answer
  • Autosomal dominant
  • Inactivating mutation or deletion of Foxp3
  • Polyendrocrinopathy
  • T reg absent or non-function

Question 8

Question
All of the following about B cell tolerance are true except?
Answer
  • Deletion of self reactive IgM B cells in bone marrow is 100% efficient
  • We all have autoreactive B cells
  • Under normal circumstances a parallel autoreactive T cell will be absent and or a T reg will be present, so you are unlikely to have T cell help for autoreactive B cells
  • The presence of autoreative B cell becomes obvious as one ages and loses T cell mediated regulation

Question 9

Question
All of the following are true about auto immune diseases except
Answer
  • MHC molecules which are able to efficiently present self antigen
  • A failure to delete or functional inactivate self reactive lymphocytes - Breakdown of immunological tolerance
  • Additional environmental and or genetic factors - Viral or bacterial infections, susceptibility genes, hormonal influences, toxins and tissue damage
  • None of the above

Question 10

Question
Ankylosing spondylitis is associated with HLA B27
Answer
  • True
  • False

Question 11

Question
People heterozygous for DQ2 and DQ8 are most susceptible to Type I Diabetes
Answer
  • True
  • False

Question 12

Question
Sympathetic ophthalmia is an example of unveiling of antigens previously not accessible to the immune systems
Answer
  • True
  • False

Question 13

Question
Molecular mimicry - an antibody of T cell response induced against a pathogen cross - reacts with a self antigen - ex Rheumatic fever - true of false
Answer
  • True
  • False

Question 14

Question
An example for intermolecular epitope spreading is Pemphigus
Answer
  • True
  • False

Question 15

Question
Over-expression of anti-inflammatory molecules and Underexpression of Pro-inflammatory molecules - is the aberrant expression seen in autoimmune diseases
Answer
  • True
  • False

Question 16

Question
Autoimmune diseases are more common in males
Answer
  • True
  • False

Question 17

Question
Smoking increases the autoimmune reaction by citrullinating the proteins
Answer
  • True
  • False

Question 18

Question
Aging increases autoimmunity due to immune senescence
Answer
  • True
  • False

Question 19

Question
All of the following about autoimmune hemolytic anemia are true except?
Answer
  • HSR III
  • Produce autoantibodies against antigens on RBCs - IgG and IgM
  • It could be drug induced ex penicillin
  • Diagnosis by Direct Coombs test

Question 20

Question
Goodpasture syndrome autoantibodies against alpha3 chain of type IV collagen in glomerular basement membrane and alveolar basement membrane
Answer
  • True
  • False

Question 21

Question
A patient presents with multiple blisters on his back and both arms. You lightly rub his skin and another blister forms because you disrupted the connection between 200 desmosomes. All of the following are true about this disorder except?
Answer
  • HSR II
  • Autoantibodies against desomogleins
  • intermolecular spreading
  • This condition is Pemphigus vulgaris

Question 22

Question
Myasthenia Gravis is due to anti-ACH receptor antibodies and Lambert-Eaton syndrome is due to auto antibodies against voltage gated Calcium channels thereby inhibiting the release of calcium
Answer
  • True
  • False

Question 23

Question
In all II and III HSR Plasmapheresis is not effective
Answer
  • True
  • False

Question 24

Question
All II and III HSR antibodies can cross the placenta and can effect the fetus
Answer
  • True
  • False

Question 25

Question
All of the following are true about IDDM except
Answer
  • Peptides associated with islet cell autoantigens Glutamic acid decarboxylase 65 (GAD65) are cross reactive with Coxsackie virus proteins
  • HSR III
  • Macrophage activation by TNFalpha and IL-1
  • Beta cell specific Th1 cells make IFNgamma

Question 26

Question
All of the following are true about Multiple sclerosis except?
Answer
  • Destruction of myelin sheath of nerve fibers in brain and spinal cord due to autoreactive T cells - Type IV HSR
  • Areas of demyelination (plaques) seen on MRI
  • Candidate antigens: Myelin basic protein and Myelin Oligodendrocyte glycoprotein
  • completely curable

Question 27

Question
All of the following are true about SLE except?
Answer
  • Most common autoimmune rheumatic disease
  • Intermolecular spreading
  • HSR IV
  • ANA test is a screening test only - anti-dsDNA, anti-snRNP or Sm(smith antigen) are also 100% specific for SLE
  • UV-B exposure and cigarette smoking are the environmental triggers

Question 28

Question
All of the following are true about Rheumatoid arthritis except?
Answer
  • Presence of Rheumatoid factor is diagnostic of Rheumatoid arthritis
  • Infliximab, Adalimumab, Etanercept TNFR-IG all are effective against RA
  • Autoreative CD4 Tb1 cells and Tb17 cells against synovial tissue autoantigen
  • None of the above

Question 29

Question
All of the following are true about Sjogren's syndrome except
Answer
  • Autoimmune destruction of exocrine glands
  • HSR III
  • Shrimer's test - to test tear production, spit test are done
  • none of the above

Question 30

Question
All of the following are true about Wegener's Granulomatosis except
Answer
  • Anti Neutrophil Cytoplasmic antibodies (ANCA)
  • Saddle nose due to destruction of the cartilage
  • cavitary lesions are characteristic on chest xray
  • more common in females

Question 31

Question
All of the following are associated with scleroderma except
Answer
  • Raynaud's syndrome
  • Sclerodactyly
  • Male predominance
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