Necrosis

Necrosis = [blank_start]unregulated[blank_end] cell death due to injury  [blank_start]Passive[blank_end] process  Indiscriminate with bystander damage  Membrane [blank_start]blebs[blank_end] but then breaks down  Cell bursts ([blank_start]lysis[blank_end]) and spills contents → inflammation  Activated by toxins released/macrophages

Types of necrosis: 1. [blank_start]Coagulative[blank_end] : ghost-like appearance inadequate blood supply denatured proteins inside cell due to acidified cytosol 2. [blank_start]liquefactive[blank_end] pus is the appearance lipid rich tissue will result in this cell proteins digested and structure is lost 3. [blank_start]caseous[blank_end] Cheese-like appearance granulomatous inflammation 4. [blank_start]gangrenous[blank_end] slow vascular blockage (dry is [blank_start]coagulative[blank_end] necrosis in the extreme) (wet is infection and is [blank_start]liquefactive[blank_end] necrosis) 5. Fat [blank_start]chalky[blank_end] deposits fatty tissue damaged and fatty acids are released into surrounding tissue