944943
Antimicrobial Drugs
- Works on Cell Wall
- Peptidoglycan cross-linking inhibition= no wall synthesis
- Penicillinase Resistant
- Naficillin
- Staph. Aureus;
except MRSA
- Interstitial Nephritis
- Staph. Aureus;
except MRSA
- Oxacillin
- Dicloxacillin
- Aztreonam
- Gram NEG RODS ONLY!!
- Gram NEG RODS ONLY!!
- Vancomycin
- Gram POSITIVE ONLY!
Multi-drug resistant
organisms
- MRSA, Enterococci, & C.diff
- MRSA, Enterococci, & C.diff
- RED MAN SYNDROME
(diffuse flushing)
Nephrotoxicity, Ototoxiicity,
Thrombophlebitis
- Gram POSITIVE ONLY!
Multi-drug resistant
organisms
- Naficillin
- NOT resistant to B-lactamase
- Penicillin (B-lactam)
- 1.Gram + organisms w/
no B-lactamase,
2.Neisseria M.
3.Treponema Pallidum
- Hemolytic Anemia
- 1.Gram + organisms w/
no B-lactamase,
2.Neisseria M.
3.Treponema Pallidum
- Ampicillin/AmOxicillin
- EXTENDED
SPECTRUM:
1.H.influenzae
2.E.coli 3.Listeria M.
4.Proteus Mirabilis
5.Salmonella
6.Shigella
- Pseudomembranous Colitis
- EXTENDED
SPECTRUM:
1.H.influenzae
2.E.coli 3.Listeria M.
4.Proteus Mirabilis
5.Salmonella
6.Shigella
- +Clavulanic Acid/ Tazobactam/ Sulbactam
(B-lactamase
inhibitor)
- Ticarcillin/
Piperacillin
- Pseudomonas
- Pseudomonas
- Cephalosporins
- First Generation
- Cefazolin/cephalexin
- Prior to surgery for Staph a.
- 1. ProteusM.
2.E.coli
3.Klebsiella
- Prior to surgery for Staph a.
- Cefazolin/cephalexin
- Vit K deficiency
- 2nd generation
- Ceftriaxone
- Meningitis and
Gonorrhea
- Meningitis and
Gonorrhea
- Ceftiazidime
- Pseudomonas
- Pseudomonas
- Ceftriaxone
- First Generation
- Penicillin (B-lactam)
- Penicillinase Resistant
- Peptidoglycan cross-linking inhibition= no wall synthesis
- Protein Synthesis Inhibitors
- 30S inhibitors
- Aminoglycosides
- Gentomycin
Neomycin
Streptomycin
- Nephrotoxicity
Ototoxicity
NM blockage
- Gentomycin
Neomycin
Streptomycin
- Tetracyclines
- Tetracycline
Deoxycycline
- Borrelia Burgdorferi
M.pneumonia
Rickettsia
Chlamydia
- Teeth discoloration
Bone growth
inhibition
Photosensitivity
- Borrelia Burgdorferi
M.pneumonia
Rickettsia
Chlamydia
- Tetracycline
Deoxycycline
- Aminoglycosides
- 50S inihibitors
- Chloramphenicol
- MENINGITIS
(H.influenza,
N. meningitis,
Strep. pneum)
- Anemia
Pancytopenia
- Anemia
Pancytopenia
- MENINGITIS
(H.influenza,
N. meningitis,
Strep. pneum)
- Erythromycin
Azithromycin
- Atypical
pneumonias
(Mycoplasma &
LEGIONELLA= Eryth #1)
Chlamydia
Strep infections
in pencillin
allergy
- Motility problems
Arrythmia
Cholestatic hepatits
Rash Eosinophilia
- Atypical
pneumonias
(Mycoplasma &
LEGIONELLA= Eryth #1)
Chlamydia
Strep infections
in pencillin
allergy
- Clindamycin
- Pseudomembranous colitis;
ASPIRATION PNEUMONIA
(alcoholics) = works against
oral anaerobes & G+ aerobes
(S.pneum) ; and oral infections
w/ mouth anaerobes
- Treats anaerobes
ABOVE the diaphragm
vs Metronidazole that
works BELOW
- Treats anaerobes
ABOVE the diaphragm
vs Metronidazole that
works BELOW
- Pseudomembranous colitis;
ASPIRATION PNEUMONIA
(alcoholics) = works against
oral anaerobes & G+ aerobes
(S.pneum) ; and oral infections
w/ mouth anaerobes
- Chloramphenicol
- 30S inhibitors
- Others:
- Isoniazid (INH)
- Myco. TB (& prophylaxis)
- Neurotoxicity
(due to similar
structure to B6)
- Neurotoxicity
(due to similar
structure to B6)
- Myco. TB (& prophylaxis)
- Rifampin
- Mycob. TB
- ORANGE Urine
- ORANGE Urine
- Mycob. TB
- TMP-SMX
- (Trimethoprim- Sulfamethoxazole)
- HIV prophylaxis Hx of recurrent UTI's
- HIV prophylaxis Hx of recurrent UTI's
- (Trimethoprim- Sulfamethoxazole)
- TB Treatment
- Prophylaxis
- Isoniazid
- Isoniazid
- Active infection treatment drugs
- Isoniazid
- Rifampin
- Ethambutol
- Pyrazinamide
- Only one that works best in LOW pH and INTRACELLULARLY
- Only one that works best in LOW pH and INTRACELLULARLY
- I/E work on the cell wall. Rif-
inhibits DNA- dependent RNA
polymerase Pyra-kills
intracellularly
- Isoniazid
- Prophylaxis
- '-floxacin'
(Fluroquinolones)
- Inhibit DNA gyrase & topoisomerase IV
- G- rods of urinary
and GI tracts;
Neisseria
- DONT take with
ANTACIDS!! GI upset;
Superinfections;
TENDONITIS; Tendon
rupture; Myalgias
- DONT take with
ANTACIDS!! GI upset;
Superinfections;
TENDONITIS; Tendon
rupture; Myalgias
- G- rods of urinary
and GI tracts;
Neisseria
- Inhibit DNA gyrase & topoisomerase IV
- Metranidazole
- Forms free radicals in the bacteria
- Treats ANAEROBIC infections
BELOW the diaphragm;
Giardia; Entamoeba;
Trichomonas; Gardnerella
vaginalis; and H.pylori
(+clarithromycin & PPI)
- Disulfiram-like rxn
w/ alcohol;
METALLIC TASTE
- Disulfiram-like rxn
w/ alcohol;
METALLIC TASTE
- Treats ANAEROBIC infections
BELOW the diaphragm;
Giardia; Entamoeba;
Trichomonas; Gardnerella
vaginalis; and H.pylori
(+clarithromycin & PPI)
- Forms free radicals in the bacteria
- Isoniazid (INH)
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