NTDs

NTDs

Formation of CNS
1. Formation
2. Shaping
  1. PCP pathway
    1. Cell fate
    2. Cytoskeletal changes
3. Bending and fusion
  1. Hingepoints
Types of NTD
1. Spina bifida
  1. pathogenesis
  2. Hydroencephaly
2. Enter text here
Predisposing factors
1. Anti-epilepsy
2. Hyperthemia
3. Hypervitaminosia
4. Diabetes
  1. Inositol
5. Fumanosin
6. Folic acid related
  1. MTHFR
  2. Autoantibodies against FR
Mouse models
1. Folate sensitive
  1. Cited2
  2. Splotch 2h
2. Folate resistant
  1. ct/ct
    1. Eyelash
    2. grhl3 cDNA
    3. change cell prolif rates
      1. reduce NT
        cell division inhibitors
      2. Increase NC
        Retinoic acid
    4. Inositol
      1. Effects
        in vivo
        in vitro
3. Diabetic
  1. SELH/Bc

Resource summary

	Created by sam.hilton over 11 years ago