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Innate Immunity :)

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User has deleted their subject information Mind Map on Innate Immunity :), created by Deleted user on 23/01/2018.
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Plymouth Med
Created by Plymouth Med over 6 years ago
Plymouth Med
Copied by Plymouth Med over 6 years ago
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Resource summary

Innate Immunity :)
  1. Physical Barriers
    1. Skin
      1. Mucosa
        1. Acidic pH
          1. Tears (antiseptic)
            1. Cilia
              1. Enzymes
                1. Microcidal molecules
                2. First Line Defense
                  1. Normal Microbial Flora
                    1. Serum Proteins
                      1. Complement (Cascade)
                        1. Classical
                          1. Antigen-Antibody
                            1. More common one
                          2. Alternative
                            1. Spontaneous
                              1. Ex: Bacterial Toxins
                              2. all 3 lead to C3 convertsase
                                1. Cleaves
                                  1. C3a
                                    1. anaphalotoxin
                                      1. Mast cell degranulation
                                        1. Release Histamine
                                          1. Increased Vasodilation
                                          2. Release Bradykinin
                                            1. Increased Vascular Permeability
                                              1. Rolling Adhesion of Leukocytes
                                                        1. Vasodilation
                                                            1. blood flow slows down
                                                              1. allows monocytes to roll along epithelial edges
                                                      2. S
                                                        1. S
                                                          1. S
                                                            1. S
                                                          2. Selectins
                                                            1. Binds to glycoproteins on leukocyte to slow it down
                                                            2. I
                                                              1. I
                                                                1. I
                                                                  1. I
                                                                2. Integrins
                                                                  1. Activated by neutrophil activation
                                                                    1. Stops monocyte
                                                                  2. L
                                                                    1. L
                                                                      1. L
                                                                        1. L
                                                                          1. L
                                                                            1. Diapedesis
                                                                              1. macrophage goes into the epithelium to site of injury
                                                                      2. Leukocyte
                                                                    2. epithelium
                                                                      1. IL-1
                                                                        1. TNF alpha
                                                                            2. Chemokines increases adhesiveness of epithelial cells
                                                                      2. Pathogen
                                                                        1. Break in Epithelium
                                                                          1. IL-8 released
                                                                            1. chemotaxis
                                                                              1. leukocytes come over
                                                                                1. 1. Neutrophils
                                                                                  1. 2. Antigen Presenting Cells
                                                                                    1. Dendritic Cells
                                                                                      1. Macrophages
                                                                                        1. Go off to lymph node to present antigen
                                                                                          1. Start of Acquired Immunity
                                                                                      2. 3. Natural Killer Cells
                                                                                        1. Detects clumps of bacteria
                                                                                          1. Clumping due to antibodies
                                                                                  2. Prostaglandins released
                                                                          2. Promotes Inflammation
                                                                            1. Loss of functionality
                                                                              1. Swelling
                                                                                1. Pain
                                                                                  1. Heat
                                                                                  2. Redness
                                                                          3. C3b
                                                                            1. Leads to cleaving of C5
                                                                              1. C5a
                                                                                1. C5b
                                                                                  1. C5b-9
                                                                                    1. Membrane Attack Complex (MAC)
                                                                                2. Complement
                                                                                  1. Opsonin
                                                                                    1. Coats bacteria
                                                                                      1. Enhances chemotaxis and phagocytosis
                                                                          4. Mannase-Binding Lectin
                                                                            1. Interact with bacteria directly
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