Copy and Edit

Innate Immunity :)

Description

User has deleted their subject information Mind Map on Innate Immunity :), created by Deleted user on 23/01/2018.
Deleted user
Mind Map by Deleted user, updated more than 1 year ago More Less
Plymouth Med
Created by Plymouth Med over 6 years ago
Plymouth Med
Copied by Plymouth Med over 6 years ago
8
0
0

Resource summary

Innate Immunity :)
  1. Physical Barriers
    1. Skin
      1. Mucosa
        1. Acidic pH
          1. Tears (antiseptic)
            1. Cilia
              1. Enzymes
                1. Microcidal molecules
                2. First Line Defense
                  1. Normal Microbial Flora
                    1. Serum Proteins
                      1. Complement (Cascade)
                        1. Classical
                          1. Antigen-Antibody
                            1. More common one
                          2. Alternative
                            1. Spontaneous
                              1. Ex: Bacterial Toxins
                              2. all 3 lead to C3 convertsase
                                1. Cleaves
                                  1. C3a
                                    1. anaphalotoxin
                                      1. Mast cell degranulation
                                        1. Release Histamine
                                          1. Increased Vasodilation
                                          2. Release Bradykinin
                                            1. Increased Vascular Permeability
                                              1. Rolling Adhesion of Leukocytes
                                                        1. Vasodilation
                                                            1. blood flow slows down
                                                              1. allows monocytes to roll along epithelial edges
                                                      2. S
                                                        1. S
                                                          1. S
                                                            1. S
                                                          2. Selectins
                                                            1. Binds to glycoproteins on leukocyte to slow it down
                                                            2. I
                                                              1. I
                                                                1. I
                                                                  1. I
                                                                2. Integrins
                                                                  1. Activated by neutrophil activation
                                                                    1. Stops monocyte
                                                                  2. L
                                                                    1. L
                                                                      1. L
                                                                        1. L
                                                                          1. L
                                                                            1. Diapedesis
                                                                              1. macrophage goes into the epithelium to site of injury
                                                                      2. Leukocyte
                                                                    2. epithelium
                                                                      1. IL-1
                                                                        1. TNF alpha
                                                                            2. Chemokines increases adhesiveness of epithelial cells
                                                                      2. Pathogen
                                                                        1. Break in Epithelium
                                                                          1. IL-8 released
                                                                            1. chemotaxis
                                                                              1. leukocytes come over
                                                                                1. 1. Neutrophils
                                                                                  1. 2. Antigen Presenting Cells
                                                                                    1. Dendritic Cells
                                                                                      1. Macrophages
                                                                                        1. Go off to lymph node to present antigen
                                                                                          1. Start of Acquired Immunity
                                                                                      2. 3. Natural Killer Cells
                                                                                        1. Detects clumps of bacteria
                                                                                          1. Clumping due to antibodies
                                                                                  2. Prostaglandins released
                                                                          2. Promotes Inflammation
                                                                            1. Loss of functionality
                                                                              1. Swelling
                                                                                1. Pain
                                                                                  1. Heat
                                                                                  2. Redness
                                                                          3. C3b
                                                                            1. Leads to cleaving of C5
                                                                              1. C5a
                                                                                1. C5b
                                                                                  1. C5b-9
                                                                                    1. Membrane Attack Complex (MAC)
                                                                                2. Complement
                                                                                  1. Opsonin
                                                                                    1. Coats bacteria
                                                                                      1. Enhances chemotaxis and phagocytosis
                                                                          4. Mannase-Binding Lectin
                                                                            1. Interact with bacteria directly
                                                                        Show full summary Hide full summary

                                                                        Want to create your own Mind Maps for free with GoConqr? Learn more.

                                                                        Similar

                                                                        Higher Level Economics
                                                                        Jim hammerton
                                                                        ACT Quiz
                                                                        Brad Hegarty
                                                                        Biology AQA 3.1.3 Osmosis and Diffusion
                                                                        evie.daines
                                                                        An Inspector Calls: Mrs Sybil Birling
                                                                        Rattan Bhorjee
                                                                        ExamTime Quick Guide to Getting Started
                                                                        Andrea Leyden
                                                                        Key Biology Definitions/Terms
                                                                        courtneypitt4119
                                                                        Strength and Limitations of research methods
                                                                        Isobel Wagner
                                                                        Laboratory Tools
                                                                        Christopher Nikolo R. Magtoto
                                                                        The Strange Case of Dr. Jekyll and Mr. Hyde
                                                                        K d
                                                                        Writing successful GCSE English essays
                                                                        Sarah Holmes
                                                                        Macbeth Quotes/Themes
                                                                        Michael LEwis
                                                                        Browse Library