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199887
Fármacos antifúngicos
Description
Mind Map on Fármacos antifúngicos, created by ricardo_chavez26 on 09/09/2013.
Mind Map by
ricardo_chavez26
, updated more than 1 year ago
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Created by
ricardo_chavez26
over 11 years ago
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Resource summary
Fármacos antifúngicos
Alilaminas
Naftifina (tópica), Terbinafina(oral, tópica)
Inhibición de escualeno
Antimetabolitos
Flucitosina (oral)
Inhibición de síntesis de ADN y ARN
Imidazoles
Ketoconazol, bifonazol, clotrimazol, econazol, miconazol, oxiconazol, sulconazol, terconazol, tioconazol
Vía tópica, oral
Inhibe enzimas lanosterol 14-alfa-desmetilasa dependientes del citocromo P-450
Triazoles
Inhiben enzimas lanosterol 14-alfa-desmetilasa dependientes de citocromo P-450
Fluconazol (oral e IV)
Buena penetración en SNC, resistencia primaria en Candida krusei y secundaria en Candida glabrata
Itraconazol (oral e IV)
Voriconazol (oral e IV)
Levaduras y formas miceliales
Candida krusei
Posaconazol (oral)
Actividad frente a cigomicetos
Ravuconazol (oral e IV)
Actividad frente a levaduras y formas miceliales
Equinocandinas
Inhibición de síntesis de glucanos de la pared celular del hongo
IV
Caspofungina
Candidiasis invasiva y aspergilosis invasiva
Anidulafungina y micafungina
Candidiasis invasiva, actividad fungicida frente a Candida
Aminocandida
Polienos
Se une a ergosterol y provoca daño oxidativo directo en la membrana
Anfotericina B (IV, tópica)
Nistatina (suspensión oral, tópica)
Inhibidor de la síntesis de quitina
Nikomicina Z (IV)
Inhibición de síntesis de quitina de la pared celular
Derivados de sordarina y azasordarina
Inhibición del factor de elongación 3
Amplio espectro de actividad, incluso frente a Pneumocystis jiroveci
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