Neurocognitive Pharmacology

Description

Psicología Flowchart on Neurocognitive Pharmacology, created by J.J. Lopez on 07/03/2022.
J.J. Lopez
Flowchart by J.J. Lopez, updated more than 1 year ago
J.J. Lopez
Created by J.J. Lopez over 2 years ago
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Resource summary

Flowchart nodes

  • Donezepil-Aricept
  • Rivastigmine-Exelon
  • Galantamine-Razadyne
  • Memantine-Namenda
  • Selective AChE Inhibitor
  • General Information
  • AChE Inhibitor
  • Inhibits Acetilcolinesterasa
  • Acetilcolinesterasa breaks down ACh
  • By inhibiting AChE, there is more ACh in the system
  • This can result in a betterment of memory
  • Mostly effective at early Dx
  • Not very effective at later stages
  • Given at Initial, moderate and severe stages
  • In CNS and PNS
  • Do to interaction with PNS, will generate GI Sx
  • Tx: Varying types of dementia
  • -Alzheimer's -Parkinson's -Lewy bodies dementia -Vascular dementia
  • S-E: Nausea, vomiting, diarrhea, muscle cramps, fatigue, weight loss
  • Will usually last 1-3 weeks
  • AChE and BuChE inhibitor
  • BuChE inhibitor
  • Inhibits  butyrylcholinesterase 
  • butyrylcholinesterase breaks down butyrylcholine 
  • butyrylcholine is very similiar to ACh
  • By inhibiting BuCHe in glial cells, there is more ACh in the system
  • This results in regulation of Dementia patients
  • Glial Cells: provides physical and metabolic support to neurons, including neuronal insulation and communication, and nutrient and waste transport.
  • Given in fast progression
  • Tx: Mild to Moderate Alzheimer's
  • S-E: Nausea, vomiting, diarrhea, weight loss, indigestion, muscle weakness
  • Selective AChE Inhibitor
  • Given at Initial, moderate and severe stages
  • Function: Neurocogntiive and behavioral
  • Function: Neurobehavioral
  • Function: Slow down neuropsicological  deterioration 
  • Tx: Mild to Moderate Alzheimer's & Vascular dementia
  • S-E: Dizziness, nausea, vomiting, diarrhea, decreased appetite, headache
  • Stimulates nicotinic receptors to release more acetylcholine in the brain
  • NMDA receptor antagonist
  • Given at moderate and severe stages, usually in cojunction with Donezepil
  • Function: Neurocognitive functions
  • Blocks the toxic effects associated with excess glutamate and regulates glutamate activation
  • Prevents the breakdown of acetylcholine
  • Prevents the breakdown of acetylcholine in the brain
  • Prevents the breakdown of acetylcholine and butyrylcholine (a brain chemical similar to acetylcholine) in the brain
  • Tx: Moderate to severe Alzheimer's disease & sometimes Vascular dementia
  • S-E:  Constipation, Dizziness, headache, diarrhea, confusion
  • Only given when there is loss of language and motor function
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