89322
Description
Flashcards by CharlottyBow, updated more than 1 year ago
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Created by CharlottyBow
over 11 years ago
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| Question | Answer |
| Protein synthesis inhibitors - Mupirocin | Narrow spectrum against gram +ve Bacteriostatic substrate analogue of isoleucyl tRNA Topical strep skin and MRSA in nares rapidly de-esterified in kidney and liver producing non antibio metabollites |
| Protein synthesis inhibitors - Linezolids e.g. oxazolidinone | Bacteriostatic against gram +ve (efflux in gram -ves restricts use) Binds to 50s and blocks binding of isoleucyl tRNA to A site of ribosome IV/Oral for skin and soft tissue and community acquired hospital pneumonia. Skin, GI, Liver, thrombo, anaemia |
| Protein synthesis inhibitors - Tetracyclines | natural and semi synthetic broad spec. Bind to 30s, prevent association of amino acyl tRNA with ribosome Mostly oral, some IV, some topical. Tigecycline - IV, skin, soft tissue and intra abdominal infections. GI, photosensitivity, CNS, deposits in bones and teeth. |
| Protein synthesis inhibitors - Aminoglycosides | naturally occurring polycatatonic compounds. aminohexose - aminocyclitol - aminohexose structure Bind to 30s - strp, spectino Bind to both - kana, tobra causes misreading of mRNA producing abnormal proteins IM/IV entero, pseu, plague, enterococcal endocarditis |
| Protein synthesis inhibitors - Chloramphenicol | Binds to 50s inhibiting peptidyl transferase activity natural/synthetic Oral/IV bone marrow depresson, gray syndroms toxixity but treats salmonella typhi |
| Protein synthesis inhibitors - Macrolides | Gram -ves especially haemophilus inf. Bind to 23s rRNA of 50s premature dissociation from p site Oral/IV Gi, jaundice |
| Protein synthesis inhibitors -Streptogramins | quinopristin and dalfopristin act in synergy as synercid and bind to 50s at different sites |
| Protein synthesis inhibitors - Lincosamides | Lincomycin and Clindamycin Oral/IV bind to 50s act similar to macrolides anaerobes and gram +ve aerobes rashes, diarrhoea and pseudomembranous collitis c.diff |
| Protein synthesis inhibitors -Fusidic acid | Interferes with elongation factor G produced from ribosome Gram +ve Topical oral iv staph infections rash jaundice |
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