503286
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 11 years ago
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| Question | Answer |
| Cylomicrons- Transport | Triacylglycerols, phospholipids and cholesterol |
| Cylomicrons- Movement | From intestine to periperal cells |
| Cylomicrons- Main Apolipoprotein | ApoB48 |
| Cylomicrons- Destruction | Cleaved by cells with LPL into Remnant particles |
| Remnant Particles- Movement | From peripheral cells to liver, where dietary cholesterol is removed |
| VLDLs- Transport | Endogenously synthesized TAGs |
| VLDL- Movement | From liver to periphery |
| VLDL's- Main Apolipoprotein | ApoB100 |
| VLDLs- Destruction | Broken down by LPL on peripheral cells into IDLs |
| LDLs- Transport | VLDL remnants- rich in cholesterol |
| LDLs- Apolipoprotein | B100 (changes conformation to bind to receptors in liver/peripheral tissue) |
| LDLs- Uptake | 80% by ApoB/E receptors, the rest recirculate |
| LDL to HDL Conversion | In peripheral tissues, excess cholesterol can be converted to HDLs by adding TAGs |
| HDL's- Transport | Cholesterol |
| HDL's- Movement | From periphery to liver |
| HDL's- Extra Role | Metabolism of other particles |
| HDL's- Main Apolipoprotein | ApoAI/AII |
| ApoAI/AII- Roles | Activation/Inhibition of LCAT |
| ApoAI/AII Structure | Repeat units known as Kringles and a protease domain |
| HTGL | Hepatic Triglyceride Lipase |
| HTGL- Role | Removes T.A.G's from passing T.A.G rich particles/ removes LGL digested remnants |
| HTGL- Location | Liver plasma membranes |
| LPL | Lipoprotein Lipase |
| LPL- Role | Digestion of chylomicrons and VLDL's |
| LPL- Location | Vascular endothelial cell membranes |
| MTP | Microsomal Triglyceride Transfer Protein- Assists in binding of TAG to VLDL |
| LCAT | Lecithin Cholesterol Acetyl Transferase |
| LCAT- Role | Esterification of cholesterol in HDLs |
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