Gluconeogenesis

Question	Answer
What are the precursors of Gluconeogenesis?	Lactate- Generated in the muscles, it travels to the liver where it is broken down into Pyruvate then goes through Gluconeogenesis to form Glucose. Amino Acid Breakdown- form gluconeogenic intermediates which thus upregulate Gluconeogenesis. Glycerol- From Beta-oxidation, can be converted to form Gluconeogenesis intermediate which can work up to form Glucose. TCA Intermediates- Stimulate Gluconeogenesis through conversion to oxaloacetate (builds up-which stimulates)
What do we input and output in Gluconeogenesis?	We input 2 pyruvate+4ATP+2GTP+NADH. We Output Glucose+4ADP+2GDP+6Pi
Where are the only 2 locations that Gluconeogenesis can occur?	Liver and the Kidney.
What do we breakdown and form in Gluconeogenesis?	Pyruvate to Glucose (Opposite to Glycolysis)
Where does Gluconeogenesis take place?	Liver
What Important Organ is the prime user of Glucose as fuel?	Brain
How are Gluconeogenesis and Glycolysis linked?	Glycolysis breaks down Glucose to Pyruvate. Gluconeogenesis forms Glucose from Pyruvate. The 2 pathways are reciprocal, when 1 pathway is active the other is inhibited.
The pathway and Intermediates in Gluconeogenesis are the same as in Glycolysis (Just other way round). However Pyruvate is broken down to Oxaloacetate before becoming Phosphoenolopyruvate.	Gluconeogenesis Specific Enzymes- Pyruvate Carboxylase, Phosphoenolpyruvate Carboxykinase, Fructose 1,6 Biphosphatase, Glucose 6 Phosphatase. "Pathway Produces Fresh Glucose"

Resource summary

	Created by Mark Arsenal about 11 years ago