Mark George
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Pathophysiology and pharmacology of malignancies lecture

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Mark George
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Malignancies

Question 1 of 13

1

Which of the following are features of cancer cells?

Select one or more of the following:

  • autonomic & immortal

  • static & aplastic

  • transformational & variable

  • anaplastic & lacking apoptosis

Explanation

Question 2 of 13

1

Which of the following can act as tumor markers?

Select one or more of the following:

  • proteins

  • vitamins

  • hormones

  • antibodies

  • antigens

Explanation

Question 3 of 13

1

Tumor markers can confirm diagnosis of some cancers.

Select one of the following:

  • True
  • False

Explanation

Question 4 of 13

1

Which of the statements below is FALSE?

Select one of the following:

  • Pheochromocytoma is a tumor of the adrenal medulla.

  • Adrenaline can act as a tumor marker.

  • PSA is a tumor marker specifically for prostate cancer

  • Tumor markers can be found in blood, urine and CSF.

Explanation

Question 5 of 13

1

Gene mutations can result in......
(Select the INCORRECT answer)

Select one of the following:

  • Repeated division of telomeres.

  • Activation of tumor suppression genes.

  • Cancer cells stimulating angiogenesis

  • Stimulation of growth promotion pathways

  • Transformation of proto-oncogenes into oncogenes.

Explanation

Question 6 of 13

1

Regarding the contribution of obesity to cancer, which of the following statements are true?

Select one or more of the following:

  • BMI greater than 30 linked to cancer.

  • The endocrine and metabolic activity of adipose tissue is thought to contribute to cancer development

  • The increased release of FFA and TNF is thought to contribute to cancer development

  • Increased levels of insulin is also linked to cancer development.

Explanation

Question 7 of 13

1

Which of the following sets of factors all increase the risk of cancer development?

Select one or more of the following:

  • CHronic inflammation, over-exertion, poor diet and television.

  • Viruses, bacteria, chronic inflammation and environmental factors

  • smoking, radiation, alcohol and shopping

  • Ulcerative colitis, chronic asthma, physical inactivity and Epstein Barr Virus

Explanation

Question 8 of 13

1

Select the true statements regarding pharmacological management of cancer.

Select one or more of the following:

  • Narcotic analgesics act to inhibit the release of substance P

  • Adverse effects of narcotic analgesics include diarrhoea, psychological disturbances and vomiting

  • Fentanyl is slow to act but has a long half life.

  • Accumulation of morphine can result in coma

  • Buprenorphine and azathioprine are used in the treatment of terminal cancer pain

Explanation

Question 9 of 13

1

Select the cytotoxic agents

Select one or more of the following:

  • Calcium channel blockers

  • Antiarbitrucins

  • Antimetabolites

  • Alkylating agents

  • Hormonal agonists

  • Hormonal inhibitors

Explanation

Question 10 of 13

1

Chlorambucil and Carboplatin target the mechanism for cell division

Select one of the following:

  • True
  • False

Explanation

Question 11 of 13

1

The antiandrogenic drug Flutamide is administered to prostate cancer sufferers.

Select one of the following:

  • True
  • False

Explanation

Question 12 of 13

1

5-fluorouacil (5-FU) is an hormonal inhibitor that acts by blocking synthesis of pyramidine nucleotides

Select one of the following:

  • True
  • False

Explanation

Question 13 of 13

1

Side effects common to alkylating agents, antibiotic-type agents and antimetabolites include

Select one or more of the following:

  • Bone marrow suppression

  • GI disturbances

  • mouth ulcers

  • impaired fertility

  • bleeding

Explanation

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