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Immunology 2

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Question 1 of 51

1

Which options are primary lymphoid organs?

Select one or more of the following:

Thymus
Bone marrow
Spleen
Peyer's patches
MALT

Explanation

Question 2 of 51

1

Which options are secondary lymphoid organs?

Select one or more of the following:

MALT
Spleen
Lymph nodes
Thymus
Bone marrow

Explanation

Question 3 of 51

1

Dendritic cells are derived from lymphoid and myeloid precursors.

Select one of the following:

True
False

Explanation

Question 4 of 51

1

Platelets are derived directly from pluripotent stem cells.

Select one of the following:

True
False

Explanation

Question 5 of 51

1

Which options do not express MHC Class 1?

Select one or more of the following:

Red blood cells
Platelets
Neutrophils
B cells
T cells

Explanation

Question 6 of 51

1

Naive B cells are derived from the

Select one of the following:

Bone marrow
Thymus
Spleen
MALT

Explanation

Question 7 of 51

1

CD4+ T cells recognise

Select one of the following:

MHC Class 1
MHC Class 2

Explanation

Question 8 of 51

1

CD8+ T cells recognise

Select one of the following:

MHC Class 1
MHC Class 2

Explanation

Question 9 of 51

1

CD16 and CD56 are both found on

Select one of the following:

NK cells
Macrophages
B cells
T cells

Explanation

Question 10 of 51

1

All leukocytes express

Select one of the following:

CD45
CD19
CD68
CD59

Explanation

Question 11 of 51

1

The most abundant leukocyte in circulation are...

Select one of the following:

Neutrophils
Macrophages
B cells
CD8+ T cells

Explanation

Question 12 of 51

1

Monocytes and Macrophages help to produce components involved in the complement system

Select one of the following:

True
False

Explanation

Question 13 of 51

1

Macrophages are able to present antigens on their surface

Select one of the following:

True
False

Explanation

Question 14 of 51

1

Monocytes have CD.....

Select one of the following:

14
56
16
15

Explanation

Question 15 of 51

1

During phagocytosis, fusion of the lysosome and phagosome leads to production of...

Select one of the following:

Phagolysosome
Early endosome
Endophagosome

Explanation

Question 16 of 51

1

Which granulocytes have major basic protein in their granules?

Select one or more of the following:

Eosinophils
Basophils
Neutrophils

Explanation

Question 17 of 51

1

Which granulocytes have lactoferrin in their granules?

Select one or more of the following:

Neutrophils
Eosinophils
Basophils

Explanation

Question 18 of 51

1

Which granulocytes do not have histamine in their granules?

Select one or more of the following:

Eosinophils
Neutrophils
Basophils

Explanation

Question 19 of 51

1

Which granulocytes have chondroitin sulphate in their granules?

Select one or more of the following:

Neutrophils
Eosinophils
Basophils

Explanation

Question 20 of 51

1

Which of these are reactive oxygen species?

Select one or more of the following:

Hypochlorous acid
Hydrogen peroxide
Superoxide
Water

Explanation

Question 21 of 51

1

The only antimicrobial peptides that macrophages use are...

Select one of the following:

Cathelicidins
Azurocidin
Defensins
Histatins

Explanation

Question 22 of 51

1

Acidification by neutrophils or macrophages is...

Select one of the following:

Bacteriocidal
Bacteriostatic
Can be both

Explanation

Question 23 of 51

1

Both macrophages and neutrophils produce ROS's.

Select one of the following:

True
False

Explanation

Question 24 of 51

1

Both macrophages and neutrophils produce NETs.

Select one of the following:

True
False

Explanation

Question 25 of 51

1

The most potent antigen present cell is...

Select one of the following:

Dendritic cells
Macrophages
Monocytes
B cells

Explanation

Question 26 of 51

1

Click on each orange point and write the correct answer.

Label the features of platelets

Explanation

Question 27 of 51

1

Most T cells are...

Select one of the following:

CD4 positive but CD8 negative
CD4 positive and CD8 positive
CD8 positive but CD4 negative

Explanation

Question 28 of 51

1

Which cytokine results in a T cell receptor being produced on an immature T cell?

Select one of the following:

IL-7
IL-10
GM-CSF
TNF-a

Explanation

Question 29 of 51

1

Self molecules are said to induce...

Select one of the following:

Tolerance
Multi-specificity
Immunogenicity

Explanation

Question 30 of 51

1

What is negative selection?

Select one of the following:

T cells with a high affinity for self antigens are killed by apoptosis
T cells with a high avidity for self antigens are killed by apoptosis
T cells with a low affinity for self antigens are killed by apoptosis
T cells with a low affinity for self antigens are allowed to mature

Explanation

Question 31 of 51

1

What is positive selection?

Select one of the following:

T cells with a low affinity for self antigens are allowed to mature
T cells with a high affinity for self antigens are allowed to mature
T cells with a high affinity for self antigens are killed off by apoptosis
T cells with a low affinity for self antigens are killed off by apoptosis

Explanation

Question 32 of 51

1

The majority of T cells do not make it through negative selection.

Select one of the following:

True
False

Explanation

Question 33 of 51

1

T cells without any stimulation also die off.

Select one of the following:

True
False

Explanation

Question 34 of 51

1

What CD do T regulatory cells have?

Select one of the following:

4
19
8

Explanation

Question 35 of 51

1

Which cells do TH1 helper cells activate?

Select one of the following:

Macrophages
B cells
Any nucleated cell
Stromal cells

Explanation

Question 36 of 51

1

Which cells do TH2 helper cells activate?

Select one of the following:

B cells
Macrophages
T cells
Stromal cells

Explanation

Question 37 of 51

1

Which cells do TH17 helper cells activate?

Select one of the following:

Stromal cells
B cells
Macrophages
T cells

Explanation

Question 38 of 51

1

What is the main effect of T reg cells?

Select one of the following:

Recruiting neutrophils
Activating macrophages
Triggering B cell proliferation and antibody secretion
Inhibition of immune response

Explanation

Question 39 of 51

1

What is the main effect of TH2 cells?

Select one of the following:

Recruiting neutrophils
Activating macrophages
Triggering B cell proliferation and antibody secretion
Inhibition of immune response

Explanation

Question 40 of 51

1

What is the main effect of TH1 cells?

Select one of the following:

Recruiting neutrophils
Activating macrophages
Triggering B cell proliferation and antibody secretion
Inhibition of immune response

Explanation

Question 41 of 51

1

What is the main effect of TH17 cells?

Select one of the following:

Recruiting neutrophils
Activating macrophages
Triggering B cell proliferation and antibody secretion
Inhibition of immune response

Explanation

Question 42 of 51

1

Which cytokine(s) tend to be released by TH17 cells?

Select one of the following:

IL-7
IL-17
TGF-beta
IL-10

Explanation

Question 43 of 51

1

Which cytokine(s) tend to be released by TH1 cells?

Select one of the following:

IL-7
IL-10
IFN-gamma
TGF-beta

Explanation

Question 44 of 51

1

Which cytokine(s) tend to be released by TH2 cells?

Select one of the following:

IL-4
TNF-a
TNF-b
PGD2

Explanation

Question 45 of 51

1

Which cytokine(s) tend to be released by CD8+ cells?

Select one of the following:

IFN-gamma
TNF-a
TGF-b
IL-4

Explanation

Question 46 of 51

1

What feature on T cells helps to induce proliferation B cells?

Select one of the following:

CD40
CD40 Ligand
mIgM
CD45

Explanation

Question 47 of 51

1

B cells have complement receptors.

Select one of the following:

True
False

Explanation

Question 48 of 51

1

As well as perforin and granzyme to kill target cells, NK cells have...

Select one of the following:

NK Cytotoxic factor
CD40 Ligand
Major basic protein
Lyophosphatase

Explanation

Question 49 of 51

1

Interferon gamma is produced by NK cells - what is its function?

Select one of the following:

Activate phagocytes
Activates B cells
Induces proliferation of T cells

Explanation

Question 50 of 51

1

NK cells have a T cell receptor.

Select one of the following:

True
False

Explanation

Question 51 of 51

1

T cells are the most abundant lymphocytes.

Select one of the following:

True
False

Explanation