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Year 2 Quiz on Apoptosis, created by gina_evans0312 on 03/12/2013.

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Apoptosis

Question 1 of 15

1

What is the main difference between apoptosis and necrosis?

Select one of the following:

  • In necrosis release of cell contents is controlled
    In apoptosis it's not

  • In apoptosis release of cell contents is controlled
    In necrosis it's not

Explanation

Question 2 of 15

1

What protein condenses during apoptosis

Select one of the following:

  • Chromatin

  • Actin

  • Myosin

Explanation

Question 3 of 15

1

What form are caspases usually found in?

Select one of the following:

  • Inactive, with their DED domain tails intact

  • Active, with their DED domain tails intact

  • Inactive, with their DED domain tails removed

  • Active, with their DED domain tails removed

Explanation

Question 4 of 15

1

What is required for caspase activation?

Select one of the following:

  • Addition of a DED domain tail

  • Removal of the DED domain tail

Explanation

Question 5 of 15

1

What are the roles of the 2 main caspases?

Select one of the following:

  • 3 is the initation
    8 does most damage

  • 8 is the initiator
    3 does most damage

Explanation

Question 6 of 15

1

Which of the following are survival/protector proteins that inhibit caspase activation?

Select one of the following:

  • BAX, BAD, PUMA

  • Bci-2, Mcl1, A1

Explanation

Question 7 of 15

1

What is required for ligand acitvated apoptosis?

Select one of the following:

  • For the receptors to contain DED domains

  • For the receptors to be bound to caspases

  • For the receptors to be expressed only in certain areas of the cell membrane

Explanation

Question 8 of 15

1

What protein inhibits the activation of apoptic receptors?

Select one of the following:

  • Flp

  • Flr

  • Fld

Explanation

Question 9 of 15

1

Name an apoptic receptor

Select one of the following:

  • Fas

  • Far

  • Fam

Explanation

Question 10 of 15

1

How does the receptor activate caspase 8?

Select one of the following:

  • By recruiting it and cleaving off the DED domain

  • By recruiting it and adding a DED domain

Explanation

Question 11 of 15

1

Name the two methods caspase 8 uses to destroy the cell

Select one or more of the following:

  • Activation of Caspase 3

  • Deactivation of Caspase 3

  • Damage to mitochondria, which releases Cyt. C

Explanation

Question 12 of 15

1

What does mitochondrial damage do to Casp 9?

Select one of the following:

  • Activates it

  • Deactivates it

Explanation

Question 13 of 15

1

What happens when essential growth factors are withdrawn from the cell?

Select one or more of the following:

  • PI3K cannot activate

  • PKB cannot activate

  • Casp 8 cannot activate

Explanation

Question 14 of 15

1

How does PKB inhibit apoptosis?

Select one of the following:

  • Releases Bad from Blc-2

  • Releases Blc2 from Bad

Explanation

Question 15 of 15

1

Identify methods which cells can use to evade apoptosis

Select one or more of the following:

  • Decreased Fas receptor expression

  • Inc Blc2 & decrease bax/bad expression

  • Loss of Casp 8

  • Increased Flp expression

  • Soluble fas to causes apoptosis in t-cells

  • Large amounts of Fas ligand produced to kill t-cells

Explanation

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