Topic 5.2 - Synthesis and Fate of Proteins

Describe how mRNA is translated into protein.
Describe several processes that ensure fidelity in translation.
Explain how signal sequences direct protein localisation to the nucleus, mitochondrion or endoplasmic reticulum.
Describe how glycoproteins are formed.
Explain how chaperones and glycosylation contribute to quality control in protein synthesis.
Give examples of post-translational modifications of proteins that occur at the time of synthesis.
Describe the main intracellular traffic pathways, including those for protein synthesis, secretion, endocytosis, transcytosis and breakdown.
List the main type of intracellular vesicle and describe how they are involved in carrying molecules around the cell.
Describe the functions of families of molecules involved in vesicular traffic, including coat proteins, the Rab family of G-proteins, SNARES and motor proteins.
Describe the various routes by which proteins are degraded within cells, including the function of the proteasome and the lysosome.
Describe the role of ubiquitin in controlling protein breakdown and the function of SUMO in controlling protein activity.

	Created by Sam Geldard about 2 years ago

Year 3 - Undergraduate Module S317 - Genes to Species (Topic 5 - Gene Expression and its Control) Note on Topic 5 - Learning Outcomes, created by Sam Geldard on 24/05/2022.