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Year 2 Quiz on cGMP Stimulated Protein Kinase & NO Synthase, created by gina_evans0312 on 03/11/2013.

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cGMP Stimulated Protein Kinase & NO Synthase

cGMP Stimulated Protein Kinase & NO Synthase

Question 1 of 18

1

What is so special about cGMPPK?

Select one of the following:

  • It's anti-parallel

  • The subunits of the dimer can swap roles of damage occurs

  • It's only found in cardiac cells

Explanation

Question 2 of 18

1

How many cGMP bind per monomer?

Select one of the following:

  • 2

  • 4

  • 6

  • 1

  • 3

Explanation

Question 3 of 18

1

Which order do the subunits go in (from N to C terminus)
A= Dimerisation Domain
B- Catalytic Domain
C= Autoinhibitory Hinge Region
D= cGMP binding sites 1 & 2

Select one of the following:

  • A-C-D-B

  • A-B-D-C

  • C-A-D-B

  • C-D-A-B

Explanation

Question 4 of 18

1

What is the purpose of the autoinhibitory hinge region?

Select one of the following:

  • Acts as a pseudosubstrate

  • Causes inhibition after a certain amount of activity

Explanation

Question 5 of 18

1

What motif does cGMP Stimulated Protein Kinase Phosphorylate?

Select one of the following:

  • Arg-Ser-X-Arg

  • Arg-Thr-X-Arg

  • Arg-Arg-X-Ser

  • Arg-Arg-X-Thr

Explanation

Question 6 of 18

1

What is the role of this protein?

Select one or more of the following:

  • The activation of cGMP dependent ion channels

  • Activates cGMP dependent phosphodiesterases

  • The activation of cGMP dependent proteins

  • Inhibits cGMP dependent phosphodiesterases

Explanation

Question 7 of 18

1

What is required for NO to be synthesized?

Select one or more of the following:

  • NO synthase

  • FMD/FAD

  • O2

  • NADP

  • NADPH

  • FMD

  • Tetrahydrobiopterin

Explanation

Question 8 of 18

1

Which of the following stimulate NO production?
A- AcH
B- Bradylunin
C- Nicotine
D- Thrombin
E- Cl-
F- Ca2+

Select one of the following:

  • A, B, D, F

  • A, D, E, F

  • B, C, D, F

Explanation

Question 9 of 18

1

Which system is NO part of?

Select one of the following:

  • Paracrine

  • Juxtracrine

  • Autocrine

  • Endocrine

Explanation

Question 10 of 18

1

NO is synthase a monomer- True or False?

Select one of the following:

  • True

  • False

Explanation

Question 11 of 18

1

How many types of NO synthase are there?

Select one of the following:

  • Constitutive

  • Inducible

  • Constitutive & Inudcible

Explanation

Question 12 of 18

1

Why is NO produced by iNOS (Immune NO Synthase)

Select one of the following:

  • It kills of pathogens

  • It's used to signal immune cells

  • It's used to bind and immobalise pathogens

Explanation

Question 13 of 18

1

NO Synthase produces a few mmol of NO over a minute- True or False?

Select one of the following:

  • True

  • False- its pmol over a minute

  • False, it's micromol in a few seconds

  • False, its pmol over a few seconds

Explanation

Question 14 of 18

1

NO Synthase contains the following, but in which order?
A-NADPH binding site
B-Calmodulin Binding Site
C-FMN centre
D- FAD centre
E-Haeme group
F- Arg, O2 and Tetrahydropterin (Active site)

Select one of the following:

  • E-F-B-C-D-A

  • A-D-B-C-F-E

  • E-F-A-C-D-B

Explanation

Question 15 of 18

1

Why are vascular endothelial cells equipped to cause vasodilation?

Select one of the following:

  • It allows them to reduce blood pressure according to need

  • It allows them to increase blood flow to wounded areas

  • It prevents damage to veins under high pressure

Explanation

Question 16 of 18

1

Which neurotransmitter effects which cells?
A- Ach
B-Vasopressin

Select one of the following:

  • Vascular Endothelial-A
    Skeletal Muscle-B

  • Vascular Endothelial- A&B
    Skeletal Muscle-A

  • Vascular Endothelial- A
    Skeletal Muscle-A&B

Explanation

Question 17 of 18

1

What is the role of nitroglycerin?

Select one of the following:

  • An explosive

  • It liberates NO from tissues

  • Causes an increase in NO synthesis

Explanation

Question 18 of 18

1

What is the role of viagra?

Select one or more of the following:

  • Inhibits phosphodiesterases

  • Prevents cGMP breakdown

  • Prolongs NO production

Explanation

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