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All four hypersensitivity reactions

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Hypersensitivity reactions

Question 1 of 28

1

All of the following are correctly matched except?

Select one of the following:

  • Type I HSR - IgE mediated

  • Type II HSR - IgA mediated

  • Type III HSR - Immune complex - IgG mediated

  • Type IV HSR - Cell mediated

Explanation

Question 2 of 28

1

All of the following are true about hygiene hypothesis except

Select one of the following:

  • Excessive hygeine

  • Overuse of antibiotics

  • Not vaccinating the child

Explanation

Question 3 of 28

1

All of the following are components of a typical adaptive response to an helminthic infection except

Select one of the following:

  • CDH4 Th1 cells

  • Cytokines - IL 3,4,5,9,10,13

  • antibodies IgE and IgG 1 and 4

  • Effector cells such as eosinophils, basophils and mast cells

Explanation

Question 4 of 28

1

The main components of type I HSR are neutrophils and lymphocytes

Select one of the following:

  • True
  • False

Explanation

Question 5 of 28

1

Sensitization to antigen involves class switching to IgE production on first contact with an allergen

Select one of the following:

  • True
  • False

Explanation

Question 6 of 28

1

All of the following are stages in HSR I except

Select one of the following:

  • Initial exposure to immunogen which results in the production of reactive B and T cells - no symptoms

  • B cell - T cell interaction - antigen activation of Th2 cells

  • Production of IL 4 + IL 13

  • Production of IgE

  • Binding of IgE to Fc Epsilon Receptor and activation/sensitization of mast cell and release of mediators

  • None of the above

Explanation

Question 7 of 28

1

The following is true about HSR I immediate and late response

Select one of the following:

  • Within minutes mast cell + Basophils will release histamine and serotonin causing wheal and flare

  • In hours Eosinophils +Th2 will release second wave of mediators prostaglandis and leukotrienes

  • Both are correct

  • None of the above

Explanation

Question 8 of 28

1

Intrinsic asthma is Type I HSR reaction

Select one of the following:

  • True
  • False

Explanation

Question 9 of 28

1

The Primary method for diagnosing HSR I is by skin testing, with the characteristic response being "wheal and flare" reaction within minutes

Select one of the following:

  • True
  • False

Explanation

Question 10 of 28

1

RAST detects IgG anti-allergen in patient's serum

Select one of the following:

  • True
  • False

Explanation

Question 11 of 28

1

All of the following are used as treatment strategies for HSR I

Select one of the following:

  • Allergen avoidance

  • Correct Th1/Th2 imbalance (not clinically feasible)

  • Block mediators either with antihistamine, lipoxygenase inhibition or steroid use

  • Correct isotype switch to IgE

  • Prevent IgE binding to mast cells to prevent IgE mediated degranulation

Explanation

Question 12 of 28

1

Epinephrine is the main treatment for anaphylaxis - true or false

Select one of the following:

  • True
  • False

Explanation

Question 13 of 28

1

In desensitization treatment the allergen binds to IgG thereby preventing IgE mediated response - true or false

Select one of the following:

  • True
  • False

Explanation

Question 14 of 28

1

Omalizumab is a mab that binds to Fc region of IgE thereby blocking the arming of mast cells - true or false

Select one of the following:

  • True
  • False

Explanation

Question 15 of 28

1

All of the following are true about HSR II except

Select one of the following:

  • HSR II is mediated by IgG or IgM not IgE

  • HSR II the antibodies bind to the self antigen on cell membranes and extracellular matrix

  • HSR II makes autoreactive antibodies

  • HSR II activates the alternate complement pathway

Explanation

Question 16 of 28

1

All of the following are mechanisms for cell damage in HSR II except?

Select one of the following:

  • recruitment of neutrophils - causing tissue injury and inflammation

  • Opsonization and Phagocytosis

  • Interfere with cellular functions - either block or stimulate cell receptors

  • All of the above

  • None of the above

Explanation

Question 17 of 28

1

All of the following are HSR II reactions except

Select one of the following:

  • Hemolytic disease of the newborn

  • Blood transfusion reactions

  • Penicillin reaction

  • Extrinsic asthma

Explanation

Question 18 of 28

1

All of the following are true regarding Hemolytic disease of the newborn (HDNB) except

Select one of the following:

  • Seen when mother is Rh+ and baby is Rh-

  • Mother is O type blood group and baby A,B or AB

  • Prevention is by giving Rhogam to the mother

  • None of the above

Explanation

Question 19 of 28

1

All of the following are non cytotoxic type II HSR diseases except

Select one of the following:

  • Myasthenia gravis

  • NDIIM

  • Graves disease

  • Pernicious anemia

  • Penicillin allergy

Explanation

Question 20 of 28

1

All of the following are cytotoxic HSR II except?

Select one of the following:

  • Erythroblastosis fetalis (Hemolytic disease of the newborn)

  • PCN reaction

  • Rheumatic fever

  • Autoimmune thrombocytopenic purpura

  • Goodpasture syndrome

  • Grave's disease

Explanation

Question 21 of 28

1

Type III HSR - damaged tissues are innocent bystanders when a circulating (soluble antigen) immune complex becomes deposited in the tissues - true or false

Select one of the following:

  • True
  • False

Explanation

Question 22 of 28

1

When immune complexes (ICs) exceed disposal the net result is inflammation locally or systemically - true or false

Select one of the following:

  • True
  • False

Explanation

Question 23 of 28

1

All of the following are Type III HSR except

Select one of the following:

  • Serum sickness

  • Farmer's lung (Arthus reaction)

  • SLE

  • Post Streptococcal glomerulonephritis (PSGN)

  • None of the above

Explanation

Question 24 of 28

1

Lumpy bumpy pattern of nephritis is characteristic of PSGN - true or false

Select one of the following:

  • True
  • False

Explanation

Question 25 of 28

1

All of the following are true about Arthus reaction except?

Select one of the following:

  • Farmer's lung is an example of Arthus reaction

  • Arthus reaction is used in the skin testing of HSR III

  • Arthus reactions are visualized in the skin

  • none of the above

Explanation

Question 26 of 28

1

All of the following are true about delayed type IV HSR except?

Select one of the following:

  • Starts 49-72 hours after antigen exposure

  • T cell release cytokines that activate macrophages resulting in cell damage

  • B cells form antibodies that are delayed in their response hence called delayed HSR

  • Mediated by Th1 cells and CD8+ cytotoxic T cells

Explanation

Question 27 of 28

1

HSR IV is an inappropriate manifestation of DTH response that normally protects against intracellular bacterial and fungal infections - true or false

Select one of the following:

  • True
  • False

Explanation

Question 28 of 28

1

All of the following are examples of IV HSR except

Select one of the following:

  • PPD

  • Poison ivy dermatitis

  • contact dermatitis due to nickel exposure

  • Celiac disease

  • PSGN

Explanation

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