By what mechanism is Huntington’s Disease inherited?
Autosomal Dominant
Autosomal Recessive
X-linked Recessive
X-linked Dominant
Multifactorial Inheritance
If your patient has an autosomal dominant condition, what are the chances that their child will get it?
100%
25%
75%
12.5%
50%
In genetics, what name is given to the phenomenon whereby as a genetic disorder is passed on from generation to generation, the symptoms of the disorder become apparent at an earlier age with each generation?
Acceleration
Penetrance
Anticipation
Heritability
Transformation
Huntington's Disease patients tend to experience which of the following symptoms?
Chorea
Myoclonus
Tic
Tremor
Huntington's disease is caused genetically via repeats of a series of bases - CAG CAT TAT TAG( CAG, CAT, TAT, TAG )
The CAG repeats in Huntington's disease occur on the 1st 2nd 3rd 10th( 1st, 2nd, 3rd, 10th ) exon encoding the poly-glutamine coronin lactase actin salazine( glutamine, coronin, lactase, actin, salazine ) protein
When an individual has more than 38 32 48 42( 38, 32, 48, 42 ) CAG repeats on the 1st exon encoding glutamine, they will develop Huntington's at some point in their life.
A normal human has less than 32 38 42 28( 32, 38, 42, 28 ) CAG repeats on the 1st exon encoding poly-glutamine
The more CAG repeats that are present, the earlier in life the individual will develop Huntington's Disease
Which of these symptoms would be inconsistent with mania with psychotic symptoms?
Normal sleep pattern
Irritability instead of elation
Delusional idea that they are being monitored by the police
Physical aggression
Flight of ideas
Bipolar I is a condition that affects roughly 1% of the British population. Is Bipolar I associated with mania or hypomania?
Mania
Hypomania
