Anthracyclines drugs are

Describe "steal liposomal"

merit of "steal liposomal"

Anthracyclines SEs + solutions (1)

Lifetime doses of Anthracyclines.
1. Doxorubicin: -----?
2. Daunorubicin: -----?
3. Epirubicin: -------?

Anthracyclines SEs + solutions (2)

Treatment for anthracycline IV extravasates are .....

What is the difference btw
1. Dexrazoxane (Zinecard®)
2. Dexrazoxane (Totect®)

Alkylating Agent is

Cyclophosphamide is closely related to ----?

cyclophosphamide requires activation by CYP450 to have an anticancer effect, the primary isoforms are -----?

What is the name of the metabolite formed by cyclophosphamide wh/ causes hemorrhagic cystitis?

The therapeutic, DNA reactive metabolite is of cyclophosphamide is ----?

acrolein is a ------?

1. Due to bladder toxicity, -------- is necessary with either IV or PO administration of cyclophosphamide.
2. During high-dose treatment, patients should receive vigorous IV -------?

AEs of cyclophosphamides

Taxanes drugs are ----

Taxanes MOA

Why do patients receive dexamethasone with docetaxel?

What are the major toxicities associated with paclitaxel and docetaxel?

Why do patients receive premedication with dexamethasone, diphenhydramine and an H2 antagonist prior to paclitaxel?

Microtubule inhibitors are

Microtubule inhibitors MOA

Ixabepilone (epithilone) is associated with -----?

Ixabepilone BBW includes ------?

Cremophor (also used as an excipient in
taxane formulations) is known to be a --------- and may lead to ----------- which can be life threatening if not treated appropriately

Cremophol EL requires ---------- as premeds

What is the purpose of Cremophor® EL in taxane and microtubulin inhibitors formulations?

vinorelbine (Navelbine®) is used for ---?

Antimetabolites

Capecitabine is available in tablets form as ------------- prodrug?

Capecitabine is an elegant drug in that it allows for -------- concentrations of --------- (the active product provided by 5-FU) in cancerous cells than in normal cells.

Activation of 5-FU through several steps to yield a metabolite which targets thymidylate synthase and acts as a suicide inhibitor is an MOA of -------------- drugs?

Capecitabine SEs are ----- ?

How do you identify drug leakage caused by “hand-and-foot syndrome”?

capecitabine carries a black box warning
of a -------?

Antibodies (moAb) that TARGETS HER2/neu and HER2(+)

Trastuzumab (Herceptin®) and pertuzumab (Perjeta®) MOA ---?

Trastuzumab (Herceptin®) and pertuzumab (Perjeta®) SEs are -----?

Trastuzumab (Herceptin®) and pertuzumab (Perjeta®) BBW is ----?

What are pretreatment drug recommendations for Trastuzumab (Herceptin®) and pertuzumab (Perjeta®) in other to avoid infusion related toxicitity?

What is the difference btw Trastuzumab (Herceptin®) and Ado-trastuzumab emtansine (Kadcyla™)

Ado-trastuzumab emtansine (Kadcyla™) BBW includes ----?

DM1 is associated with

Fam-trastuzumab deruxtecan-nxki (Enhertu®) indication is -----?

Fam-trastuzumab deruxtecan-nxki (Enhertu®) MOA?

Fam-trastuzumab deruxtecan-nxki (Enhertu®) AES

Kinase Inhibitors are

Lapatinib and Neratinib MOA?

Lapatinib and Neratinib AEs ---?

Lapatinib (Only) SEs ---?

Lapatinib BBW

Lapatinib indication ---?

Neratinib (Nerlynx®) indication ----?