Mer Scott
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PHCY320 (Reproductive and Sexual Health) Quiz on L10 Reproductive Pharmacology​, created by Mer Scott on 26/09/2019.

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Mer Scott
Created by Mer Scott about 5 years ago
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L10 Reproductive Pharmacology​

Question 1 of 16

1

Choose ALL correct statements about pregnancy physiology.

Select one or more of the following:

  • Increase in plasma volume thus volume of distribution, requires increase in dose in some medications to achieve therapeutic levels.

  • Increase in cardiac output.​

  • Decrease in glomerular filtration rate and renal clearance, can require lower doses and longer dosing intervals

  • Induction of hepatic enzymes​ reduces levels of medications with hepatic metabolism​, can affect anti epileptic medication levels. ​

  • Placenta​ decreases volume of distribution and adds an additional compartment in the distribution and elimination of medications​

  • Hypercoagulable state​ requires adjustment of anticoagulants and careful monitoring of coagulation parameters​

  • Decreased thyroid function​

Explanation

Question 2 of 16

1

Placental transfer of medications​
1. Factors promoting transfer​:
-
​- molecular weight (250-500)​

2. Factors reducing transfer​
- Highly
- binding​
- Molecular weight (>500-1000)​

Drag and drop to complete the text.

    Lipophilic
    Low
    ionized
    Protein
    High

Explanation

Question 3 of 16

1

Teratogenic medicines can have a direct effect (eg thalidomide, isotretinoin), or act through effects on oxygen transfer or nutrient supply to the developing fetus (eg methotrexate)​

Select one of the following:

  • True
  • False

Explanation

Question 4 of 16

1

Known specific teratogens​ - match to effect:
- first trimester phocomelia​
- late first trimester nasal hypoplasia, third trimester fetal anticoagulation and intracranial bleeding​
- first trimester spontaneous abortion, second and third trimester renal hypoplasia​
- first trimester-cardiac and NTD​ (neural tube defects)
- NTDs and facial hypoplasia​

Drag and drop to complete the text.

    Thalidomide
    Warfarin
    ACE inhibitors
    Valproic acid
    Carbamazepine

Explanation

Question 5 of 16

1

Opiod dependence:
Cessation during pregnancy can result in fetal and fetal death​
Usual course of action is maintenance​
Detoxification by tapering can be performed in carefully selected patients with fetal

Drag and drop to complete the text.

    withdrawal
    methadone
    monitoring

Explanation

Question 6 of 16

1

Select all antimicrobial classes that are generally safe in pregnancy​.

Select one or more of the following:

  • Beta-lactams​

  • Nitrofurantoin​

  • Aminoglycosides

  • Vancomycin​

  • Fluoroquinolones

  • Tetracyclines

Explanation

Question 7 of 16

1

Lamivudine and zidovudine for HIV in pregnancy reduces vertical transmission to the neonate from 15-30% to < 2%.

Select one of the following:

  • True
  • False

Explanation

Question 8 of 16

1

Corticosteroids (betamethasone preferred, or dexamethasone) can be administered to reduce the incidence of intraventricular hemorrhage and reduce the risk of respiratory distress syndrome in preterm (<34 weeks) deliveries​

Select one of the following:

  • True
  • False

Explanation

Question 9 of 16

1

Group B streptococcus can cause neonatal sepsis, pneumonia, meningitis​. With penicillin prophylaxis, risk is reduced to 1:600 in known carriers​.

Select one of the following:

  • True
  • False

Explanation

Question 10 of 16

1

_______ administered to patients delivering at <30 weeks gestation reduces the risk of cerebral palsy from 3.5% to 1.9% (RR 0.55)​.

Select one of the following:

  • Magnesium sulfate

  • Penicillin

  • Valaciclovir

Explanation

Question 11 of 16

1

Congenital Adrenal Hyperplasia​ is an genetic condition causing increased androgen production in a female fetus. Maternal administration of suppresses the adrenal glands​. Must be initiated in pregnancy​.

Drag and drop to complete the text.

    autosomal recessive​
    dexamethasone
    fetal
    early

Explanation

Question 12 of 16

1

Uterine stimulants for labour induction, PPH:

Ergot alkaloids​ (May cause hypertensive crisis in hypertensives or when administered by the route​)
Prostaglandins (Categories are potent uterine stimulants​)

Drag and drop to complete the text.

    IV
    E and F
    Oxytocin

Explanation

Question 13 of 16

1

Uterine relaxants/Tocolytics​:
Beta 2 agonists​ (ritodrine, terbutaline and salbutamol, no effect on delaying )
Calcium channel blockers​ (Nifedipine​, for preterm)
Oxytocin receptor antagonists​ (Atosiban​. Doesn't work though - just as good)
Nitrates​ (Nitroglycerin and isosorbide dinitrate, mediated relaxation of smooth muscle​. Good for twins or C section)
Prostaglandin synthetase inhibitors​ (blocks synthesis of prostaglandins via COX, limited use <h)

Drag and drop to complete the text.

    preterm labour
    effective
    placebo
    cGMP
    48

Explanation

Question 14 of 16

1

Contraceptives:
- Estrogen component inhibits through suppression of
- Progesterone: Inhibits ovulation by suppressing the LH surge, thick cervical barrier​, ovum transport is altered​, implantation is hampered by changes​

Drag and drop to complete the text.

    FSH and LH
    ovulation
    mucous
    endometrial

Explanation

Question 15 of 16

1

Metformin can be used as a fertility treatment to induce ovulation.

Select one of the following:

  • True
  • False

Explanation

Question 16 of 16

1

Physiologic bladder contraction is mediated by acetlycholine at post-ganglionic receptors (M3)​. Treatment of abnormal contraction ( bladder or detrusor overactivity) is therefor mainly agents​ like atropine, propanetheline, solifenacin. Common side effects: dry mouth and eyes, blurred vision, tachycardia, pruritis, sedation, headache, constipation​. Contraindication in narrow angle and urinary retention.

Incontinence due to reduced outlet resistance​ is usually treated surgically​. receptors contract the urinary sphincter​. Ephedrine and pseudoephedrine minimally effective (only cases)​. (SNRI) contracts the sphincter during filling with no effect on relaxation with voiding​.

Drag and drop to complete the text.

    muscarinic
    overactive
    anticholinergic
    glaucoma
    Alpha-adrenergic
    mild
    Duloxetine

Explanation