Clinical action limit

+/- 1SD =? % population? For 2? For 3?

Critical Difference

Formula for Critical Difference?

What is the assumption of the Therapeutic window?

When is a drug w/ a narrow therapeutic window acceptable?

What do half-lives influence?

Clearance is influenced by?

Different tissues = diff profusion rates
Example?

Dosing intervals of how many half lives until drug accumulation?

Bioavailability formula?