Matthew Coulson
Quiz by , created more than 1 year ago

Multiple Myeloma, AL Amyloidosis, MGUS and Waldenstrom's Macroglobulinaemia

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Matthew Coulson
Created by Matthew Coulson over 5 years ago
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Myeloma and Other Plasma Cell Disorders

Question 1 of 28

1

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Immunoglobulins are antibodies produced by B cells/Plasma cells that are made up of ( 2, 1, 3 ) heavy chains and ( 2, 1, 3 ) light chains

Explanation

Question 2 of 28

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Which of the immunoglobulins has a pentameric structure?

Select one of the following:

  • IgM

  • IgG

  • IgA

Explanation

Question 3 of 28

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Which of the immunoglobulins has a dimeric structure?

Select one of the following:

  • IgM

  • IgA

  • IgG

Explanation

Question 4 of 28

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Which of the immunoglobulins have monomeric structures?

Select one or more of the following:

  • IgM

  • IgG

  • IgA

  • IgE

  • IgD

Explanation

Question 5 of 28

1

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cells have an eccentric 'clock face nucleus' on H&E Stain

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Question 6 of 28

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Plasma cells are characterised by their ( open, closed ) chromatin

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Question 7 of 28

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Monoclonal immunoglobulins are all derived from clonal expansion of one single B cell. Monoclonal immunoglobulins are also known as

Explanation

Question 8 of 28

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Paraproteins = ( Monoclonal, Polyclonal ) Immunoglobulins

Explanation

Question 9 of 28

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Paraproteins are a marker of an underlying clonal B cell disorder

Select one of the following:

  • True
  • False

Explanation

Question 10 of 28

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What is the best form of investigation for detecting Paraproteins

Select one of the following:

  • Immunophenotyping by Flow Cytometry

  • Serum Electrophoresis

  • Fluorescence In-Situ Hybridisation

  • Cell Morphology

Explanation

Question 11 of 28

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Paraproteins found on Serum Electrophoresis tend to present in the ( Gamma, Beta, Albumin, Alpha-1, Alpha-2 ) band

Explanation

Question 12 of 28

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After serum electrophoresis has been conducted to detect paraproteins, serum should then be conducted in order to classify the abnormal protein band

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Question 13 of 28

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Bence Jones Protein is a monoclonal immunoglobulin light chain which is detected by ( urine, serum, bone marrow, CSF ) electrophoresis

Explanation

Question 14 of 28

1

The presence of Bence Jones Protein in the urine is suggestive of which two of the following conditions?

Select one or more of the following:

  • Multiple Myeloma

  • Waldenström's Macroglobulinemia

  • Monoclonal Gammopathy of Undetermined Significance (MGUS)

  • Alpha heavy chain disease

  • Acute Lymphoblastic Leukaemia

Explanation

Question 15 of 28

1

Which of the following is most common condition causative of paraproteinaemia?

Select one of the following:

  • Multiple Myeloma

  • Monoclonal gammopathy of undetermined significance (MGUS)

  • Waldenstrom's Macroglobulinemia

Explanation

Question 16 of 28

1

Monoclonal gammopathy of undetermined significance (MGUS) is a benign (premalignant) condition which can predispose to Multiple Myeloma

Select one of the following:

  • True
  • False

Explanation

Question 17 of 28

1

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Myeloma causes ( renal, liver, heart ) failure and increased ( bone breakdown, blood pressure, erythrocytosis, sodium levels )

Explanation

Question 18 of 28

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Myeloma is classified based on which type of monoclonal antibody is produced. What is the most common type of Myeloma?

Select one of the following:

  • IgG Myeloma

  • IgE Myeloma

  • IgA Myeloma

  • IgD Myeloma

  • IgM Myeloma

Explanation

Question 19 of 28

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Due to bone breakdown occurring as part of Myeloma, it also typically causes raised ( Calcium, Sodium, Potassium, Phosphate ) levels in the blood

Explanation

Question 20 of 28

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The paraproteins in Myeloma bring about renal failure by blocking the renal

Explanation

Question 21 of 28

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Paraproteins blocking the renal tubules as part of Myeloma forms small aggregations leading to what is known as nephropathy

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Question 22 of 28

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Myeloma tends to affect those in their ( 60s, 40s, 20s, teens )

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Question 23 of 28

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Levels of in the blood should be monitored in order to monitor the response of a Myeloma patient to Chemotherapy.

Explanation

Question 24 of 28

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Which of the following should be avoided in Myeloma patients?

Select one of the following:

  • NSAIDs

  • Amoxicillin

  • Antipsychotics

  • Antiemetics

  • Paracetamol

Explanation

Question 25 of 28

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Which drug type should be given to myeloma patients in order to correct their hypercalcaemia and reduce their bone pain?

Explanation

Question 26 of 28

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Monoclonal gammopathy of undetermined significance (MGUS) can be diagnosed when there is a paraprotein level of ( <30g/l, <20g/l, <50g/l, <60g/l ) and a bone marrow plasma cell level of ( <10%, <20%, <30%, <40%, <50% ). There must also be no evidence of any end organ damage (e.g. renal failure, bone marrow failure, etc)

Explanation

Question 27 of 28

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A plasma cell immunoglobulin disorder is suspected in a patient. When a sample from the patient was stained using Congo Red and placed under polarising light it showed an 'apple-green' birefringence. What condition is the patient suffering from?

Explanation

Question 28 of 28

1

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Waldenstrom’s macroglobulinaemia is a condition which characteristically involves ( IgM, IgG, IgA, IgE, IgD ) Paraproteins

Explanation

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