Matthew Coulson
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Honours Degree Medicine (Haematology - Week 2) Quiz on Introduction To Haemostasis , created by Matthew Coulson on 04/03/2019.

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Matthew Coulson
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Introduction To Haemostasis

Introduction To Haemostasis

Question 1 of 25

1

Primary Haemostasis =
Secondary Haemostasis =

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    Formation of Fibrin Clot
    Formation of Platelet Plug

Explanation

Question 2 of 25

1

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Platelets are formed on the surface of which type of cell?

Explanation

Question 3 of 25

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As a platelet has a lifespan of ( 7-10 days, 10-14 days, 14-21 days ), a patient on e.g. aspirin should have this medication stopped this period of time before surgery to avoid any unnecessary bleeding.

Explanation

Question 4 of 25

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Platelets are formed on the surface of megakaryocytes which are found within the bone marrow

Select one of the following:

  • True
  • False

Explanation

Question 5 of 25

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Von Willebrand Factor binds to Factor in the circulation. Without WVF the aforementioned factor would be broken down in the blood.

Explanation

Question 6 of 25

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Factor VIII is released from Von Willebrand Factor by action of (Factor )

Explanation

Question 7 of 25

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Von Willebrand factor also forms part of the platelet mesh that forms in response to bleeding, holding the platelets together.

Select one of the following:

  • True
  • False

Explanation

Question 8 of 25

1

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Reduced number of platelets in the blood is known as

Explanation

Question 9 of 25

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The commonest inherited bleeding disorder is a deficiency of

Explanation

Question 10 of 25

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Which usually results in a more serious bleed?

Select one of the following:

  • Primary Haemostasis failure

  • Secondary Haemostasis failure

Explanation

Question 11 of 25

1

Failure of primary haemostasis typically causes which 3 of the following?

Select one or more of the following:

  • Epistaxis

  • Conjunctival bleeding

  • Menorrhagia

  • Ischaemic stroke

  • Coronary artery infarction

Explanation

Question 12 of 25

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If you were concerned about the failure of primary haemostasis you would check the count in the blood.

Explanation

Question 13 of 25

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Coagulation Cascade (1):
Tissue Factor binds with Factor

Explanation

Question 14 of 25

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Coagulation Cascade (2):
TF-VIIa Complex activates Factor to Factor .

In the meantime, TF-VIIa also activates Factor to Factor . This Factor then binds with Factor and this complex then also activates Factor to Factor

Explanation

Question 15 of 25

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Coagulation Cascade (3):
Factor Xa then binds with Factor to form the enzyme , which facilitates the conversion of (Factor ) to (Factor )

Explanation

Question 16 of 25

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Coagulation Cascade (4):
Thrombin (Factor IIa) then goes about activating Factor to Factor , in turn releasing it from its binding to , whilst also activating Factor to Factor

Explanation

Question 17 of 25

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Coagulation Cascade (5):
The main function of Thrombin, however, is in the activation of (Factor I) to (Factor Ia).

Explanation

Question 18 of 25

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Coagulation Cascade (6):
Finally, soluble Fibrin produced by thrombin-mediated activation is organised into crosslinked Fibrin by action of Factor

Explanation

Question 19 of 25

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Fibrin is broken down into Fibrin Degradation Products (e.g. D-dimers) via which enzyme?

Explanation

Question 20 of 25

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Plasminogen --> Plasmin is mediated by which enzyme, which is thus used clinically as a thrombolytic agent?

Explanation

Question 21 of 25

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Screening tests for Fibrin Clot Formation:
: Tests TF-VIIa complex activating factor X so that the Xa/Va complex (prothrombinase) can be produced.
: Tests VIIIa/IXa complex activating Factor X so that the Xa/Va complex (prothrombinase) can be produced.

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    Activated Partial Thromboplastin Time
    Prothrombin Time

Explanation

Question 22 of 25

1

Anti-Thrombin III binds to ... thus inhibiting secondary haemostasis

Select one of the following:

  • Thrombin (Factor IIa) only

  • Thrombin (Factor IIa) & Prothrombinase (Xa/Va complex)

  • Prothrombinase (Xa/Va complex) only

  • TF-VIIa & VIIIa/IXa complexes only

  • Thrombin (Factor IIa), Prothrombinase (Xa/Va complex) & the TF-VIIa and VIIIa/IXa complexes

Explanation

Question 23 of 25

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Thrombin can bind to an endothelial cell forming thrombomodulin, which in turn activates Protein and Protein (give in alphabetical order).

Explanation

Question 24 of 25

1

Proteins C & S affect which complexes?

Select one of the following:

  • Prothrombinase (Xa/Va complex) only

  • Prothrombinase (Xa/Va complex) & TF-VIIa complex

  • Prothrombinase (Xa/Va complex) & VIIIa/IXa complex

Explanation

Question 25 of 25

1

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Deficiency of clotting factors is called
Increased tendency to form clots is called

Explanation

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