Iron in Health and Disease

Question 1 of 26

1

Forms of iron:
Ferric = ❌
Ferrous = ❌

Drag and drop to complete the text.

Fe2+

Fe3+

Explanation

Question 2 of 26

1

There is no mechanism for iron excretion.

Select one of the following:

True
False

Explanation

Question 3 of 26

1

Fill the blank space to complete the text.

Approximately mg of iron is absorbed by the body per day.

Explanation

Question 4 of 26

1

Fill the blank space to complete the text.

Iron absorption occurs mainly in which part of the small bowel?
The

Explanation

Question 5 of 26

1

Iron absorption is decreased by alcohol consumption.

Select one of the following:

True
False

Explanation

Question 6 of 26

1

Select from the dropdown lists to complete the text.

Duodenal cytochrome B, found in the luminal surface, is responsible for ( reducing, oxidising ) ( ferric, ferrous ) iron to ( ferrous, ferric ) iron

Explanation

Question 7 of 26

1

Fill the blank space to complete the text.

is the main regulator of iron absorption. In cases of haemochromatosis, this structure binds to ferroportin and causes its degradation, thus disabling the transfer of iron to transferrin

Explanation

Question 8 of 26

1

Assessment of body iron levels:
❌ = Measure Haemoglobin concentration
❌ = Measure % saturation of transferrin with iron
❌ = Measure serum ferritin

Drag and drop to complete the text.

Storage Iron

Transport Iron

Functional Iron

Regulated Iron

Explanation

Question 9 of 26

1

Select from the dropdown list to complete the text.

Transferrin has ( 2, 4, 6, 8 ) binding sites for iron

Explanation

Question 10 of 26

1

❌ = Transferrin bound to iron
❌ = Transferrin not bound to iron

Drag and drop to complete the text.

Holotransferrin

Apotransferrin

Explanation

Question 11 of 26

1

Select from the dropdown list to complete the text.

Ferritin can store up to 4000 ( ferric, ferrous ) ions

Explanation

Question 12 of 26

1

Which 4 of the follows factors can increase serum ferritin?

Select one or more of the following:

Inflammation
Sepsis
Malignancy
Liver injury
Kidney Injury
Hypoxia
Anaemia

Explanation

Question 13 of 26

1

Fill the blank space to complete the text.

Name this clinical sign which can occur due to iron deficiency.

Explanation

Question 14 of 26

1

Fill the blank space to complete the text.

Iron deficiency can also cause inflammation and scarring of the corner of the mouth.
This sign is called

Explanation

Question 15 of 26

1

Select from the dropdown list to complete the text.

Iron deficiency causes a ( microcytic, macrocytic ) anaemia

Explanation

Question 16 of 26

1

Select from the dropdown list to complete the text.

There are greater requirements for iron in ( women and children, women, men, men and children ) thus they are more likely to develop iron deficiency.

Explanation

Question 17 of 26

1

As well as poor dietary intake, which of the following can also cause iron deficiency anaemia?

Select one or more of the following:

Menorrhagia
Gastric Ulcers
NSAIDs
Haematuria
Coeliac Disease
Ulcerative Colitis

Explanation

Question 18 of 26

1

The two types of haemochromatosis are primary and secondary:
❌ haemochromatosis usually is the result of transfusions or iron loading anaemias.
❌ haemochromatosis is caused by a defect in the genes that control how much iron you absorb from food.

Drag and drop to complete the text.

Secondary

Primary

Explanation

Question 19 of 26

1

Fill the blank space to complete the text.

Hereditary Haemochromatosis is a primary haemochromatosis that typically arises due to a mutation of the HFE gene causing a decreased synthesis of which regulative protein?

Explanation

Question 20 of 26

1

Haemochromatosis can cause erectile dysfunction in males

Select one of the following:

True
False

Explanation

Question 21 of 26

1

Which three of the following can be caused by haemochromatosis?

Select one or more of the following:

Weakness/fatigue
Joint pains
Cirrhosis
Hypothyroidism
Cluster headaches
Trigeminal neuralgia

Explanation

Question 22 of 26

1

Fill the blank space to complete the text.

Hereditary Haemochromatosis most commonly occurs due to mutations in the gene

Explanation

Question 23 of 26

1

Fill the blank space to complete the text.

The initial treatment of choice for hereditary haemochromatosis in non-anaemic individuals is weekly

Explanation

Question 24 of 26

1

The most common cause of death for those suffering from Hereditary Haemochromatosis is ...

Select one of the following:

Diabetes
Hepatoma
Cardiac Failure

Explanation

Question 25 of 26

1

Secondary Iron Overload should be treated with weekly venesection.

Select one of the following:

True
False

Explanation

Question 26 of 26

1

Primary Iron Overload. E.g. ❌. Should be treated with ❌
Secondary Iron Overload. E.g. ❌. Should be treated with ❌

Drag and drop to complete the text.

weekly venesection

iron chelating agents

Thalassaemia/Transfusion

Hereditary Haemochromatosis

	Created by Matthew Coulson over 5 years ago

Honours Degree Medicine (Haematology - Week 1) Quiz on Iron in Health and Disease, created by Matthew Coulson on 02/03/2019.

Iron in Health and Disease

Question 1 of 26

Forms of iron: Ferric = ❌ Ferrous = ❌

Drag and drop to complete the text.

Explanation

Question 2 of 26

There is no mechanism for iron excretion.

Select one of the following:

Explanation

Question 3 of 26

Fill the blank space to complete the text.

Approximately mg of iron is absorbed by the body per day.

Explanation

Question 4 of 26

Fill the blank space to complete the text.

Iron absorption occurs mainly in which part of the small bowel? The

Explanation

Question 5 of 26

Iron absorption is decreased by alcohol consumption.

Select one of the following:

Explanation

Question 6 of 26

Select from the dropdown lists to complete the text.

Duodenal cytochrome B, found in the luminal surface, is responsible for reducing oxidising( reducing, oxidising ) ferric ferrous( ferric, ferrous ) iron to ferrous ferric( ferrous, ferric ) iron

Explanation

Question 7 of 26

Fill the blank space to complete the text.

is the main regulator of iron absorption. In cases of haemochromatosis, this structure binds to ferroportin and causes its degradation, thus disabling the transfer of iron to transferrin

Explanation

Question 8 of 26

Assessment of body iron levels: ❌ = Measure Haemoglobin concentration ❌ = Measure % saturation of transferrin with iron ❌ = Measure serum ferritin

Drag and drop to complete the text.

Explanation

Question 9 of 26

Select from the dropdown list to complete the text.

Transferrin has 2 4 6 8( 2, 4, 6, 8 ) binding sites for iron

Explanation

Question 10 of 26

❌ = Transferrin bound to iron ❌ = Transferrin not bound to iron

Drag and drop to complete the text.

Explanation

Question 11 of 26

Select from the dropdown list to complete the text.

Ferritin can store up to 4000 ferric ferrous( ferric, ferrous ) ions

Explanation

Question 12 of 26

Which 4 of the follows factors can increase serum ferritin?

Select one or more of the following:

Explanation

Question 13 of 26

Fill the blank space to complete the text.

Name this clinical sign which can occur due to iron deficiency.

Explanation

Question 14 of 26

Fill the blank space to complete the text.

Iron deficiency can also cause inflammation and scarring of the corner of the mouth. This sign is called

Explanation

Question 15 of 26

Select from the dropdown list to complete the text.

Iron deficiency causes a microcytic macrocytic( microcytic, macrocytic ) anaemia

Explanation

Question 16 of 26

Select from the dropdown list to complete the text.

There are greater requirements for iron in women and children women men men and children( women and children, women, men, men and children ) thus they are more likely to develop iron deficiency.

Explanation

Question 17 of 26

As well as poor dietary intake, which of the following can also cause iron deficiency anaemia?

Select one or more of the following:

Explanation

Question 18 of 26

The two types of haemochromatosis are primary and secondary: ❌ haemochromatosis usually is the result of transfusions or iron loading anaemias. ❌ haemochromatosis is caused by a defect in the genes that control how much iron you absorb from food.

Drag and drop to complete the text.

Explanation

Question 19 of 26

Fill the blank space to complete the text.

Hereditary Haemochromatosis is a primary haemochromatosis that typically arises due to a mutation of the HFE gene causing a decreased synthesis of which regulative protein?

Explanation

Question 20 of 26

Haemochromatosis can cause erectile dysfunction in males

Forms of iron:
Ferric = ❌
Ferrous = ❌

Iron absorption occurs mainly in which part of the small bowel?
The

Duodenal cytochrome B, found in the luminal surface, is responsible for ( reducing, oxidising ) ( ferric, ferrous ) iron to ( ferrous, ferric ) iron

Assessment of body iron levels:
❌ = Measure Haemoglobin concentration
❌ = Measure % saturation of transferrin with iron
❌ = Measure serum ferritin

Transferrin has ( 2, 4, 6, 8 ) binding sites for iron

❌ = Transferrin bound to iron
❌ = Transferrin not bound to iron

Ferritin can store up to 4000 ( ferric, ferrous ) ions

Iron deficiency can also cause inflammation and scarring of the corner of the mouth.
This sign is called

Iron deficiency causes a ( microcytic, macrocytic ) anaemia

There are greater requirements for iron in ( women and children, women, men, men and children ) thus they are more likely to develop iron deficiency.

The two types of haemochromatosis are primary and secondary:
❌ haemochromatosis usually is the result of transfusions or iron loading anaemias.
❌ haemochromatosis is caused by a defect in the genes that control how much iron you absorb from food.

Primary Iron Overload. E.g. ❌. Should be treated with ❌
Secondary Iron Overload. E.g. ❌. Should be treated with ❌