Med Student
Quiz by , created more than 1 year ago

AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU

213
3
0
Med Student
Created by Med Student over 5 years ago
Close

AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU

Question 1 of 33

1

Antifungals are:

Select one or more of the following:

  • tetracyclines

  • imidazoles

  • echinocandims

  • triazols

Explanation

Question 2 of 33

1

Synthetic antifungal drugs are

Select one or more of the following:

  • Nystatin

  • Itraconazole

  • Ketoconazole

  • Fluconazole

Explanation

Question 3 of 33

1

Antifungal antibiotics are:

Select one or more of the following:

  • Nystatin

  • Tetracycline

  • Gentamycin

  • Amphotericin B

Explanation

Question 4 of 33

1

Azoles:

Select one or more of the following:

  • are fungistatic

  • inhibit cell wall synthesis

  • inhibit ergosterol synthesis

  • inhibit hepatic CYP450 enzymes

Explanation

Question 5 of 33

1

lmidazoles are:

Select one or more of the following:

  • Fluconazole and ltraconazole

  • Miconazole and Econazole

  • Given topically

  • Given systematically

Explanation

Question 6 of 33

1

Ketoconazole is:

Select one or more of the following:

  • the only imidazole that can be given orally

  • used for treatment of bacterial skin infections

  • used topically for cutaneous fungal infections

  • used intravenously for treatment of systemic fungal infections

Explanation

Question 7 of 33

1

Fluconazole:

Select one or more of the following:

  • it is non- steroidal anti-inflammatory drug

  • is triazole antifungal drug

  • is administered orally or intravenously

  • is excreted mainly unchanged with the urine

Explanation

Question 8 of 33

1

ADRs of azole antifungals are:

Select one or more of the following:

  • hepatotoxicity

  • endocrine disorders

  • nephrotoxicity

  • nausea, vomiting

Explanation

Question 9 of 33

1

Point the correct statements for Nystatin:

Select one or more of the following:

  • has fungistatic activity

  • causes gastrointestinal disturbances

  • is effective against Trichomonas vaginalis

  • is effective against Candida species

Explanation

Question 10 of 33

1

ADRs of Amphoteracin B are:

Select one or more of the following:

  • renal impairment

  • hypokalemia

  • hypotension

  • liver impairment

Explanation

Question 11 of 33

1

Antiviral drugs act by following mechanisms

Select one or more of the following:

  • inhibition of viral “uncoating”

  • inhibition of viral DNA or RNA synthesis

  • inhibition of viral proteases

  • inhibition of viral penetration into the cell

Explanation

Question 12 of 33

1

Point out the correct statements for Aciclovir:

Select one or more of the following:

  • it inhibits viral DNA polymerase

  • it is used for “treatment of herpesvirus infections

  • it inhibits neuraminidase enzyme

  • can be applied topically, orally or intravenously

Explanation

Question 13 of 33

1

ADRs of Aciclovir are:

Select one or more of the following:

  • hepatotoxicity

  • renal impairment

  • local irritation

  • encephalopathy (at high i.v. doses)

Explanation

Question 14 of 33

1

Drugs for prevention and treatment of flu are:

Select one or more of the following:

  • Aciclovir (Zovirax)

  • Amantadin (Symmetrel)

  • Rimantadin (Flumadine)

  • Oseltamivir (Tamiflu)

Explanation

Question 15 of 33

1

Mechanism of action of Oseltamivir (Tamiflu) is

Select one or more of the following:

  • interference with the function of the viral M2 protein

  • inhibition of specific neuraminidase enzyme

  • inhibition of reverse transcriptases

  • inhibition of proteases

Explanation

Question 16 of 33

1

For Amantadine and Rimantadine is true:

Select one or more of the following:

  • resistance can develop rapidly

  • they are effective against both type A and type B influenza

  • they are effective against type A influenza viruses

  • they interfere with the function of the viral M2 protein and block uncoating of the Virus particles

Explanation

Question 17 of 33

1

Mechanisms of action of drugs for treatment of HIV infection are:

Select one or more of the following:

  • inhibition of reverse transcriptase

  • inhibition of HIV protease

  • inhibition of HIV entry into the host cell

  • inhibition of the insertion of proviral DNA. into the host cell genome

Explanation

Question 18 of 33

1

Point out the correct statements for Zidovudin;

Select one or more of the following:

  • it blocks HIV reverse transcriptase

  • it blocks HIV protease

  • it is a nucleoside analogue

  • it can cause anemia and neutropenia

Explanation

Question 19 of 33

1

ADRS of Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) are:

Select one or more of the following:

  • peripheral neuropathy

  • pancreatitis

  • polymyositis

  • glaucoma

Explanation

Question 20 of 33

1

HIV protease inhibitors are:

Select one or more of the following:

  • Zidovudin

  • Indinavir

  • Ritonavir

  • Aciclovir

Explanation

Question 21 of 33

1

For HIV protease inhibitors is true:

Select one or more of the following:

  • protease inhibition prevents maturation of the viral particles

  • they are enzyme inducers

  • they are enzyme inhibitors

  • they are combined with other antiretroviral drugs in the treatment of HIV infection

Explanation

Question 22 of 33

1

ADRs of HIV protease inhibitors are:

Select one or more of the following:

  • hyperlipidaemia

  • insulin resistance and hyperglycaemia

  • hypoglycaemia

  • fat redistribution

Explanation

Question 23 of 33

1

Inhibitor of both hepatitis B virus (HBV) and HIV reverse transcriptases is:

Select one or more of the following:

  • Zidovudin

  • Lamivudin

  • Aciclovir

  • lndinavir

Explanation

Question 24 of 33

1

Protease inhibitor for treatment of chronic hepatitis C infection is:

Select one or more of the following:

  • Aciclovir

  • Telaprevir

  • Zidovudin

  • Oseltamivir

Explanation

Question 25 of 33

1

Antimycobacterial drugs are:

Select one or more of the following:

  • Rifampicin

  • Isoniazid

  • Ethambutol

  • Amoxicillin

Explanation

Question 26 of 33

1

Rifampicin (Rifampin):

Select one or more of the following:

  • is bactericidal antibiotic with antimycobacterial activity

  • is antiviral drug

  • is broad spectrum antibiotic

  • is enzyme inducer

Explanation

Question 27 of 33

1

Mechanism of action of Rifampicin (Rifampin) is

Select one or more of the following:

  • inhibition of cell wall synthesis

  • inhibition of 50 S ribosomal subunit

  • inhibition of DNA-dependent RNA polymerase

  • increased cell membrane permeability

Explanation

Question 28 of 33

1

ADRs of Rifampicin (Rifampin) are:

Select one or more of the following:

  • heart failure

  • orange-red color of urine and other secretions

  • hepatotoxicity

  • hypoglycaemia

Explanation

Question 29 of 33

1

Point out the correct statements for lsoniazid:

Select one or more of the following:

  • inhibits the synthesis of essential for mycobacteria mycolic acid

  • it is metabolized by, acetylation

  • it is specific for treatment of M. Tuberculosis

  • it is active against broad spectrum of bacteria

Explanation

Question 30 of 33

1

ADRs of lsoniazld are:

Select one or more of the following:

  • renal impairment

  • peripheral neuropathy

  • convulsions

  • hepatitis

Explanation

Question 31 of 33

1

lsoniazid-induced peripheral neuropathy can be avoided by:

Select one or more of the following:

  • supplementation with vitamin B1

  • supplementation with vitamin A

  • supplementation with vitamin B6

  • supplementation with vitamin B12

Explanation

Question 32 of 33

1

ADRs of Pyrazinamide are:

Select one or more of the following:

  • hepatotoxicity

  • arrhythmia

  • hyperuricaemia

  • hypoglycaemia

Explanation

Question 33 of 33

1

Ethambutol:

Select one or more of the following:

  • is bacteriostatic antimycobacterial drug

  • may cause liver failure

  • may cause optic neuritis

  • inhibits synthesis of the mycobacterial cell wall

Explanation