Matthew Coulson
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Disorders of the Neuromuscular Junction & Muscle given on 26/09/2018

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Matthew Coulson
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Disorders of the Neuromuscular Junction & Muscle

Disorders of the Neuromuscular Junction & Muscle

Question 1 of 14

1

Lambert Eaton Myasthenic Syndrome is a autoimmune disease whereby antibodies attack and destroy ...

Select one of the following:

  • Presynaptic Vesicles

  • Presynaptic Calcium Channels

  • Postsynaptic Receptors

Explanation

Question 2 of 14

1

Lambert Eaton Myasthenic Syndrome typically causes muscle weakness in which parts of the body?

Select one of the following:

  • Distal limbs (arms and legs)

  • Proximal limbs (arms and legs)

  • Typically legs only

  • Typically arms only

Explanation

Question 3 of 14

1

60% of patients with Lambert-Eaton Myasthenic Syndrome have an underlying malignancy. Which malignancy does it most commonly present with?

Select one of the following:

  • Small cell lung cancer

  • Adenocarcinoma of the lung

  • Squamous cell lung cancer

  • Large cell lung cancer

  • Breast cancer

  • Renal cancer

Explanation

Question 4 of 14

1

What is the most common disorder of the neuromuscular junction?

Select one of the following:

  • Lambert-Eaton Myasthenic Syndrome

  • Myasthenia Gravis

  • Neuromyotonia

  • Congenital Myasthenia

Explanation

Question 5 of 14

1

Fill the blank space to complete the text.

Myasthenia Gravis is an autoimmune condition whereby the body develops autoantibodies against receptors

Explanation

Question 6 of 14

1

Select from the dropdown list to complete the text.

Symptoms of Myasthenia Gravis only tend to start once ACh receptors are reduced to ( 30, 60, 5 )% of normal

Explanation

Question 7 of 14

1

Which of the following structures is also known to play a part in Myasthenia Gravis?

Select one of the following:

  • Thymus

  • Bone Marrow

  • Thalamus

  • Pituitary Gland

  • Adrenal Gland

Explanation

Question 8 of 14

1

Males tend to typically present with Myasthenia Gravis in their 30s whereas woman tend to present in their 60s-70s

Select one of the following:

  • True
  • False

Explanation

Question 9 of 14

1

The difference between Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome is that ...

Select one of the following:

  • Myasthenia Gravis tends to present mostly in the proximal legs, but not the arms.

  • Myasthenia Gravis tends to present mostly in the proximal arms, but not the legs.

Explanation

Question 10 of 14

1

Whilst Myasthenia Gravis typically presents with proximal weakness of the proximal leg muscles, it also tends to cause weakness in which of the following?

Select one or more of the following:

  • Extraocular muscles

  • Facial muscles

  • Carpal muscles

  • Tarsal muscles

  • Abdominal muscles

  • Investing fascia muscles

Explanation

Question 11 of 14

1

Select from the dropdown list to complete the text.

The initial therapy for most patients with myasthenia gravis is an oral acetylcholinesterase inhibitor, usually ( Pyridostigmine, Physostigmine, Neostigmine, Rivastigmine )

Explanation

Question 12 of 14

1

Aminoglycoside antibiotics impair neuromuscular transmission and can cause clinically significant muscle weakness, resulting in respiratory depression in myasthenia gravis patients.
Therefore, which of the following medications should be avoided in such patients?

Select one of the following:

  • Gentamicin

  • Ceftriaxone

  • Amoxicillin

  • Metronidazole

  • Doxycycline

Explanation

Question 13 of 14

1

Fill the blank space to complete the text.

Inability to relax voluntary muscle after vigorous effort is known as .

Explanation

Question 14 of 14

1

Fill the blank space to complete the text.

Rhabdomyolysis releases high amounts of into the plasma thus causing Acute Kidney Injury (AKI)

Explanation

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