Physiology III: Excitatory and Inhibitory Neurotransmission in the CNS

Question 1 of 20

1

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There is a higher concentration of ( sodium, potassium ) on the outside of the cell and ( potassium, sodium ) inside the cell

Explanation

Question 2 of 20

1

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The is a significantly ( higher, lower ) concentration of Calcium extracellularly.

Explanation

Question 3 of 20

1

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Na flows inwards, causing ( depolarisation, hyperpolarisation ) which is ( excitatory, inhibitory )
Ca flows inwards, causing ( depolarisation, hyperpolarisation ) which is ( excitatory, inhibitory )
Cl flows inwards, causing ( hyperpolarisation, depolarisation ) which is ( inhibitory, excitatory )
K flows outwards, causing ( hyperpolarisation, depolarisation ) which is ( inhibitory, excitatory )

Explanation

Question 4 of 20

1

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Based on the previous question, will a drug that acts as a Na channel antagonist be excitatory or inhibitory?
( Inhibitory, Excitatory, Neither )

Explanation

Question 5 of 20

1

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Based on the previous question, will a drug that acts as a Potassium channel antagonist be excitatory or inhibitory?
( Excitatory, Inhibitory )

Explanation

Question 6 of 20

1

Events at the Synapse are mostly mediated by means of ..

Select one of the following:

Calcium Channels
Sodium Channels
Potassium Channels
Chlorine Channels

Explanation

Question 7 of 20

1

There are two types of receptors upon which neurotransmitters can act.
❌: Direct gating, whereby the receptor is an integral part of the channel it controls
❌: Indirect gating, whereby the receptor and the channel it controls are distinct from one another.

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Ionotropic Receptor

Metabotropic Receptor

Synapotropic Receptor

Explanation

Question 8 of 20

1

Label the receptor types shown in the diagram below.

Drag an answer into the correct orange point.

Ionotropic Receptors

Synapotropic Receptors

Metabotropic Receptors

Explanation

Question 9 of 20

1

The major excitatory neurotransmitter is ...

Select one of the following:

GABA
Glutamate
Glycine
Dopamine

Explanation

Question 10 of 20

1

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However, Glutamate can sometimes also elicit inhibitory effects via ( metabotropic, ionotropic ) glutamate receptors

Explanation

Question 11 of 20

1

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Ionotropic Glutamate Receptors:
NMDA receptors mediate ( slow, fast ) excitatory synaptic transmission in the CNS
Non-NMDA receptors mediate ( fast, slow ) excitatory synaptic transmission in the CNS

Explanation

Question 12 of 20

1

The major inhibitory neurotransmitter is ...

Select one of the following:

Glutamine
GABA
Glycine
Dopamine

Explanation

Question 13 of 20

1

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As GABA is an inhibitory Neurotransmitter, it tends to mediate which of the following ions.
( Potassium & Chlorine, Potassium & Sodium, Sodium & Chlorine, Sodium & Calcium )

Explanation

Question 14 of 20

1

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Ionotropic GABA receptors tend to mediate ( Chlorine channels, Potassium channels )
Metabotropic GABA receptors tend to mediate ( Potassium channels, Chlorine channels )

Explanation

Question 15 of 20

1

❌ Receptors are faster and act simply as 'on-off' switches for channels

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Ionotropic

Metabotropic

Explanation

Question 16 of 20

1

❌): Depolarising change in resting membrane potential caused by actions of neurotransmitters.
❌): Hyperpolarising change change in resting potential caused by actions of neurotransmitters.

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Excitatory Post-Synaptic Potential (EPSP

Inhibitory Post-Synaptic Potential (IPSP

Explanation

Question 17 of 20

1

A change in resting membrane potential caused by EPSP or IPSP that is not of sufficient magnitude to cross the threshold for an action potential is called ...

Select one of the following:

An Almost There Potential
A Graded Potential
A Median Potential
A Charted Potential

Explanation

Question 18 of 20

1

Fill the blank space to complete the text.

Which neurotransmitter are excitatory neurons most likely to release?

Explanation

Question 19 of 20

1

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Neurotransmitters are released in discrete packages called ( Quanta, Bundles, Quota )

Explanation

Question 20 of 20

1

Label the diagram below relating to cells of the cerebellum.

Drag an answer into the correct orange point.

Mossy Fibre

Granule Cell

Stellate Cell

Purkinje Cell

Basket Cell

Parallel Fibres

Climbing Fibre

	Created by Matthew Coulson over 6 years ago

Excitatory and Inhibitory Neurotransmission in the CNS given on 4/9/2018

Physiology III: Excitatory and Inhibitory Neurotransmission in the CNS

Question 1 of 20

Select from the dropdown lists to complete the text.

There is a higher concentration of sodium potassium( sodium, potassium ) on the outside of the cell and potassium sodium( potassium, sodium ) inside the cell

Explanation

Question 2 of 20

Select from the dropdown list to complete the text.

The is a significantly higher lower( higher, lower ) concentration of Calcium extracellularly.

Explanation

Question 3 of 20

Select from the dropdown lists to complete the text.

Explanation

Question 4 of 20

Select from the dropdown list to complete the text.

Based on the previous question, will a drug that acts as a Na channel antagonist be excitatory or inhibitory? Inhibitory Excitatory Neither( Inhibitory, Excitatory, Neither )

Explanation

Question 5 of 20

Select from the dropdown list to complete the text.

Based on the previous question, will a drug that acts as a Potassium channel antagonist be excitatory or inhibitory? Excitatory Inhibitory( Excitatory, Inhibitory )

Explanation

Question 6 of 20

Events at the Synapse are mostly mediated by means of ..

Select one of the following:

Explanation

Question 7 of 20

There are two types of receptors upon which neurotransmitters can act. ❌: Direct gating, whereby the receptor is an integral part of the channel it controls ❌: Indirect gating, whereby the receptor and the channel it controls are distinct from one another.

Drag and drop to complete the text.

Explanation

Question 8 of 20

Label the receptor types shown in the diagram below.

Drag an answer into the correct orange point.

Explanation

Question 9 of 20

The major excitatory neurotransmitter is ...

Select one of the following:

Explanation

Question 10 of 20

Select from the dropdown list to complete the text.

However, Glutamate can sometimes also elicit inhibitory effects via metabotropic ionotropic( metabotropic, ionotropic ) glutamate receptors

Explanation

Question 11 of 20

Select from the dropdown lists to complete the text.

Ionotropic Glutamate Receptors: NMDA receptors mediate slow fast( slow, fast ) excitatory synaptic transmission in the CNS Non-NMDA receptors mediate fast slow( fast, slow ) excitatory synaptic transmission in the CNS

Explanation

Question 12 of 20

The major inhibitory neurotransmitter is ...

Select one of the following:

Explanation

Question 13 of 20

Select from the dropdown list to complete the text.

As GABA is an inhibitory Neurotransmitter, it tends to mediate which of the following ions. Potassium & Chlorine Potassium & Sodium Sodium & Chlorine Sodium & Calcium( Potassium & Chlorine, Potassium & Sodium, Sodium & Chlorine, Sodium & Calcium )

Explanation

Question 14 of 20

Select from the dropdown lists to complete the text.

Ionotropic GABA receptors tend to mediate Chlorine channels Potassium channels( Chlorine channels, Potassium channels ) Metabotropic GABA receptors tend to mediate Potassium channels Chlorine channels( Potassium channels, Chlorine channels )

Explanation

Question 15 of 20

❌ Receptors are faster and act simply as 'on-off' switches for channels

Drag and drop to complete the text.

Explanation

Question 16 of 20

❌): Depolarising change in resting membrane potential caused by actions of neurotransmitters. ❌): Hyperpolarising change change in resting potential caused by actions of neurotransmitters.

Drag and drop to complete the text.

Explanation

Question 17 of 20

A change in resting membrane potential caused by EPSP or IPSP that is not of sufficient magnitude to cross the threshold for an action potential is called ...

Select one of the following:

Explanation

Question 18 of 20

Fill the blank space to complete the text.

Which neurotransmitter are excitatory neurons most likely to release?

Explanation

Question 19 of 20

Select from the dropdown list to complete the text.

Neurotransmitters are released in discrete packages called Quanta Bundles Quota( Quanta, Bundles, Quota )

Explanation

Question 20 of 20

Label the diagram below relating to cells of the cerebellum.

Drag an answer into the correct orange point.

There is a higher concentration of ( sodium, potassium ) on the outside of the cell and ( potassium, sodium ) inside the cell

The is a significantly ( higher, lower ) concentration of Calcium extracellularly.

Based on the previous question, will a drug that acts as a Na channel antagonist be excitatory or inhibitory?
( Inhibitory, Excitatory, Neither )

Based on the previous question, will a drug that acts as a Potassium channel antagonist be excitatory or inhibitory?
( Excitatory, Inhibitory )

There are two types of receptors upon which neurotransmitters can act.
❌: Direct gating, whereby the receptor is an integral part of the channel it controls
❌: Indirect gating, whereby the receptor and the channel it controls are distinct from one another.

However, Glutamate can sometimes also elicit inhibitory effects via ( metabotropic, ionotropic ) glutamate receptors

Ionotropic Glutamate Receptors:
NMDA receptors mediate ( slow, fast ) excitatory synaptic transmission in the CNS
Non-NMDA receptors mediate ( fast, slow ) excitatory synaptic transmission in the CNS

As GABA is an inhibitory Neurotransmitter, it tends to mediate which of the following ions.
( Potassium & Chlorine, Potassium & Sodium, Sodium & Chlorine, Sodium & Calcium )

Ionotropic GABA receptors tend to mediate ( Chlorine channels, Potassium channels )
Metabotropic GABA receptors tend to mediate ( Potassium channels, Chlorine channels )

❌): Depolarising change in resting membrane potential caused by actions of neurotransmitters.
❌): Hyperpolarising change change in resting potential caused by actions of neurotransmitters.

Neurotransmitters are released in discrete packages called ( Quanta, Bundles, Quota )