Inflammation and Cytokines - Absite

Injury to endothelium causes what?

Role of Platelet-Derived Growth Factor
PDGF

Role of Epidemal Growth Factor
(EGF)

Role of Fibroblastic Growth Factor
(FGF)

What is platelet-activating factor (PAF)?

Chemotactic Factors for Inflammatory cells

Chemotactic Factors for Fibroblasts

Angiogenesis Factors

Epithelialization factors

PMNs lifespan in blood vs in tissue

Lifespan of Platelets

Mast Cells

Basophils

Histamine

Bradykinin

Enzyme that inactivates bradykinin in lung

Precursor for Nitric Oxide

How Nitric Oxide works

Effects of Endothelin

Main initial cytokine response to injury and infection are release of what?

Effects of TNF-alpha

Main source for TNF-alpha

Effects of IL-1

Why do you get a fever with atelectiasis?

IL-6

IL-8

IL-10

Interferons

Selectins

Beta-2 integrins

What molecules are found on endothelial cells and involved with transendothelial migration (diapedesis)?

What activates the classic compliment pathway?

What activates the alternative complement pathway?

Factors associated with the classic complement pathway

Factors associated with alternative complement pathway

What factor is common to and is the convergence point to both classic and alternative complement pathways?

Anaphylatoxins

What is the membrane attack complex (MAC)?

Opsonization

Complements associated with chemotaxis for inflammatory cells

Effects of PGI2 and PGE2

NSAIDs

Aspirin

Steroid MoA

Pathway that prostaglandins use

Pathway Leukotrienes Use

What are the slow-reacting substances of anaphylaxis?

What are the effects of slow-reacting substances of anaphylaxis?

Leukotriene that is chemotactic for inflammatory cells

Catecholamine peak after injury

Where is Norephinephrine released from?

Where is epinephrine release from?

Neuroendocrine response to injury

CXC chemokines

Oxidants

Primary mediator of Reperfusion Injury

Chronic Granulomatous Disease

Primary Mechanism of Injury for oxygen radicals

Respiratory Burst