Michael Jardine
Quiz by , created more than 1 year ago

PHSI3012 02-2 Limitless replicative potential of cancer cells Content: * Hallmarks of Cancer * Cellular proliferation * Mortality vs immortality * Telomeres * Telomerase * ALT

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Michael Jardine
Created by Michael Jardine over 6 years ago
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PHSI3012 02-2 Limitless replicative potential of cancer cells

Question 1 of 11

1

True or false:
Cells which have entered senescence have a large, flattened morphology "like poached eggs".

Select one of the following:

  • True
  • False

Explanation

Question 2 of 11

1

Mutations in p53 and/or Rb can lead to:

Select one of the following:

  • Bypassing senescence and crisis.

  • Bypassing senescence and entering crisis.

  • Entering crisis.

  • [none of the above]

Explanation

Question 3 of 11

1

Cells in "crisis" have which of the following traits?
(select all that apply)

Select one or more of the following:

  • Massive cell death

  • Reduced cell death

  • Increased genomic stability

  • Genomic instability

Explanation

Question 4 of 11

1

The Hayflick limit is:

Select one of the following:

  • The number of divisions a cell can undergo before entering senescence.

  • (not this one)

Explanation

Question 5 of 11

1

Select from the dropdown list to complete the text.

Telomeres shorten by ~( 5 - 15, 50 - 150, 500 - 1,500, 5,000 - 15,000, 130 - 210, 2,000 - 40,000 ) bp with each round of cell division.

Explanation

Question 6 of 11

3

Fill the blank space to complete the text.

There are two [main?] telomere maintenance mechanisms. These are Telomerase and ALT.
What does ALT stand for?

Explanation

Question 7 of 11

1

Which [non-cancerous] cell type does NOT have shortening telomeres during replication?

Select one of the following:

  • Germ line cells

  • Stem cells

  • Cardiomyocytes

Explanation

Question 8 of 11

1

Telomerase is:

Select one of the following:

  • An enzyme

  • A protein

  • A molecule

Explanation

Question 9 of 11

1

Which telomere maintenance mechanism is used in the majority of cancers?

Select one of the following:

  • Telomerase

  • ALT

Explanation

Question 10 of 11

3

Telomerase can be detected using which of the following methods:
(select all that apply)

Select one or more of the following:

  • TRAP (Telomere Repeat Amplification Protocol) assay

  • TRF (Terminal Restriction Fragment) assay

  • APBs (ALT-associated PML Bodies)

  • C-circle assay

  • Movement of the telomere tag

Explanation

Question 11 of 11

3

ALT can be detected using which of the following methods?
(select all that apply)

Select one or more of the following:

  • TRAP (Telomere Repeat Amplification Protocol) assay

  • TRF (Terminal Restriction Fragment) assay

  • APBs (ALT-associated PML Bodies)

  • C-circle assay

  • Movement of the telomere tag

Explanation

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